Maternal Contributions to Preterm Delivery
Maternal Contributions to Preterm Delivery
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DOI：
10.1093/aje/kwp324
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发表时间：
2009-12-01
影响因子：
5
通讯作者：
Melbye, Mads
中科院分区：
文献类型：
--
作者：
Boyd, Heather A.;Poulsen, Gry;Melbye, Mads
早产 (PTD) 是一种复杂的特征，具有重要的家庭因素。然而，尚未建立具体的继承模式。作者研究了该妇女及其伴侣家庭中的 PTD 对她患 PTD 风险的影响。作者将丹麦国家登记册的出生信息与丹麦家庭关系数据库的谱系信息联系起来，记录了 1978 年至 2004 年发生的 1,107,124 例单胎活产。比较了有和没有各种 PTD 病史的女性，估计了风险比。既往患有 PTD 的女性复发 PTD 的风险大大增加（风险比 = 5.6，95% 置信区间：5.5、5.8）；然而，她们的 PTD 风险不受伴侣与其他女性生早产儿史的影响。女性母亲、同父异母姐妹或同父异母姐妹的 PTD 也会增加其 PTD 风险（风险比 = 1.6，95% 置信区间：1.5、1.6），而其同父异母姐妹、男性亲属的女性伴侣或伴侣家庭成员的 PTD 不会影响她的 PTD 风险。从极早期到晚期 PTD，所有孕龄的遗传模式都是相似的。 PTD 风险的很大一部分是通过女性谱系传递的影响来解释的，这表明印记或线粒体遗传发挥了作用。
Preterm delivery (PTD) is a complex trait with a significant familial component. However, no specific inheritance patterns have been established. The authors examined the contribution of PTDs in both the woman's family and her partner's family to her risk of PTD. The authors linked birth information from Danish national registers with pedigree information from the Danish Family Relations Database for 1,107,124 live singleton deliveries occurring from 1978 to 2004. Risk ratios were estimated comparing women with and without various PTD histories. Women with previous PTDs were at greatly increased risk of recurrent PTD (risk ratio = 5.6, 95% confidence interval: 5.5, 5.8); however, their PTD risk was unaffected by a partner's history of preterm children with other women. PTDs to a woman's mother, full sisters, or maternal half-sisters also increased her PTD risk (risk ratio = 1.6, 95% confidence interval: 1.5, 1.6), whereas PTDs in her paternal half-sisters, the female partners of her male relatives, or members of her partner's family did not affect her PTD risk. Inheritance patterns were similar for all gestational ages from very early through late PTD. The substantial portion of PTD risk explained by effects passed through the female line suggests a role for either imprinting or mitochondrial inheritance.