Central command does not decrease cardiac parasympathetic efferent nerve activity during spontaneous fictive motor activity in decerebrate cats
Central command does not decrease cardiac parasympathetic efferent nerve activity during spontaneous fictive motor activity in decerebrate cats
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DOI：
10.1152/ajpheart.01296.2010
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发表时间：
2011-04-01
影响因子：
4.8
通讯作者：
Liang, Nan
中科院分区：
文献类型：
--
作者：
Kadowaki, Akito;Matsukawa, Kanji;Liang, Nan
张文忠，张文忠.在去大脑猫的自发性虚构运动活动中，中央指令并不减少心脏副交感传出神经的活动。美国生理学杂志心脏循环生理学300：H1373-H1385，2011年。首次发表于2011年2月4日; doi：10.1152/ajpheart.01296.2010. -为了研究心脏迷走神经传出神经活动（CVNA）的撤回是否主要控制运动开始时的心动过速，在未麻醉的去大脑猫中自发发生的虚构运动活动期间直接评估CVNA和心脏交感传出神经活动（CSNA）的反应。在心动过速反应之前，CSNA在运动活动开始时突然增加71 +/-12%。CSNA的增加持续4 - 5 s，并恢复到基线，即使运动活动没有结束。心率增加6 +/-1次/分，与CSNA增加的时间过程相同。与此相反，CVNA从来没有减少，但增加整个运动活动，在平均动脉血压（MAP）的上升平行。在运动开始后5秒，CVNA的峰值增加为37 +/-9%。MAP逐渐升高至21 +/-2 mmHg，并在整个自发运动活动中持续。部分去窦弓神经（SAD）使MAP-CSNA和MAP-CVNA关系的压力反射敏感性减弱至对照的22 - 33%。尽管部分SAD使CSNA的初始增加减弱至对照组的53%，但CSNA的增加在整个运动活动过程中持续存在。相反，部分SAD几乎消除了运动活动期间CVNA的增加，尽管MAP升高了31 ± 1 mmHg。由于传入输入从肌肉受体和动脉压力感受器是不存在的或大大衰减的部分SAD条件下，只有中央命令在自发虚构的运动活动在去大脑猫。因此，在自发运动活动期间，中枢指令可能引起心脏交感神经流出的激活，但不产生心脏副交感神经流出的撤回。
Kadowaki A, Matsukawa K, Wakasugi R, Nakamoto T, Liang N. Central command does not decrease cardiac parasympathetic efferent nerve activity during spontaneous fictive motor activity in decerebrate cats. Am J Physiol Heart Circ Physiol 300: H1373-H1385, 2011. First published February 4, 2011; doi:10.1152/ajpheart.01296.2010.-To examine whether withdrawal of cardiac vagal efferent nerve activity (CVNA) predominantly controls the tachycardia at the start of exercise, the responses of CVNA and cardiac sympathetic efferent nerve activity (CSNA) were directly assessed during fictive motor activity that occurred spontaneously in unanesthetized, decerebrate cats. CSNA abruptly increased by 71 +/- 12% at the onset of the motor activity, preceding the tachycardia response. The increase in CSNA lasted for 4-5 s and returned to the baseline, even though the motor activity was not ended. The increase of 6 +/- 1 beats/min in heart rate appeared with the same time course of the increase in CSNA. In contrast, CVNA never decreased but increased throughout the motor activity, in parallel with a rise in mean arterial blood pressure (MAP). The peak increase in CVNA was 37 +/- 9% at 5 s after the motor onset. The rise in MAP gradually developed to 21 +/- 2 mmHg and was sustained throughout the spontaneous motor activity. Partial sinoaortic denervation (SAD) blunted the baroreflex sensitivity of the MAP-CSNA and MAP-CVNA relationship to 22-33% of the control. Although partial SAD blunted the initial increase in CSNA to 53% of the control, the increase in CSNA was sustained throughout the motor activity. In contrast, partial SAD almost abolished the increase in CVNA during the motor activity, despite the augmented elevation of 31 +/- 1 mmHg in MAP. Because afferent inputs from both muscle receptors and arterial baroreceptors were absent or greatly attenuated in the partial SAD condition, only central command was operating during spontaneous fictive motor activity in decerebrate cats. Therefore, it is likely that central command causes activation of cardiac sympathetic outflow but does not produce withdrawal of cardiac parasympathetic outflow during spontaneous motor activity.