Functional hemispheric lateralization for language in patients with schizophrenia
Functional hemispheric lateralization for language in patients with schizophrenia
复制标题
DOI：
10.1016/j.schres.2013.06.003
复制
发表时间：
2013-09-01
影响因子：
4.5
通讯作者：
Dollfus, Sonia
中科院分区：
文献类型：
--
作者：
Alary, Mathieu;Delcroix, Nicolas;Dollfus, Sonia
背景：据广泛报道，精神分裂症患者表现出半球偏侧化减少。然而，还没有研究评估语言区域半球解剖和功能不对称之间的关系。本研究旨在确定精神分裂症患者左半球偏侧化的减少是否与灰质体积不对称有关。这项研究首次使用偏侧性功能指数来分析专门参与语言任务的全局功能网络。方法：27 名惯用右手的精神分裂症患者和 54 名惯用右手的对照受试者接受了功能性磁共振成像 (fMRI) 和语音听力范式。计算功能偏侧指数 (FLI)（Wilke, M. 和 Lidzba, K.，2007。LI-tool：评估功能 MR 数据偏侧化的新工具箱。J NeurosciMethods.163, 128-136）。灰质体积不对称指数（GVAI）是根据功能语言网络计算得出的。结果：精神分裂症患者的左半球偏侧化显着减少。在健康受试者中，GVAI 和 FLI 之间存在正相关性，而在精神分裂症患者中没有发现这种相关性。 讨论：本研究首次报告了健康受试者中解剖和功能不对称之间的显着关系，但在精神分裂症患者中却没有。虽然与对照组相比，精神分裂症患者的语言功能向左偏侧减少，但这种功能异常与灰质体积不对称无关。 (C) 2013 Elsevier B.V. 保留所有权利。
Background: It is widely reported that patients with schizophrenia exhibit decreased hemispheric lateralization. However, no study has evaluated relationships between the hemispheric anatomical and functional asymmetry in language areas. The present study aimed to determine whether decreased leftward hemispheric lateralization could be related to asymmetry of the grey matter volume in patients with schizophrenia. This investigation was the first to use a functional index of laterality to analyze the global functional network specifically involved in the language task.Methods: Twenty-seven right-handed patients with schizophrenia and 54 right-handed control subjects underwent a session of a functional magnetic resonance imaging (fMRI) with a speech listening paradigm. Functional laterality indices (FLI) were calculated (Wilke, M. and Lidzba, K., 2007. LI-tool: a new toolbox to assess lateralization in functional MR-data. J Neurosci Methods. 163, 128-136). The indices of asymmetry in the volume of grey matter (GVAIs) were computed from the functional language network.Results: Patients with schizophrenia exhibited significantly decreased leftward hemispheric lateralization. There was a positive correlation between GVAIs and FLIs in healthy subjects, while no such correlation was seen in patients with schizophrenia.Discussion: This study reports for the first time a significant relationship between the anatomical and functional asymmetry in healthy subjects, but not in patients with schizophrenia. While decreased leftward functional lateralization for language was observed in patients with schizophrenia compared to the control group, this functional abnormality was not related to asymmetry in the volume of grey matter. (C) 2013 Elsevier B.V. All rights reserved.