Ketoacidosis occurs in both Type 1 and Type 2 diabetes - a population-based study from Northern Sweden
Ketoacidosis occurs in both Type 1 and Type 2 diabetes - a population-based study from Northern Sweden
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DOI：
10.1111/j.1464-5491.2008.02461.x
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发表时间：
2008-07-01
影响因子：
3.5
通讯作者：
Eriksson, J. W.
中科院分区：
文献类型：
--
作者：
Wang, Z. H.;Kihl-Selstam, E.;Eriksson, J. W.
目的：确定糖尿病酮症酸中毒（DKA）在成人2型和1型糖尿病患者在瑞典北方的发生，并确定是否DKA提出了不同的临床图片在2型与1型diabetic subjects.Methods相比，在1997-2000年诊断DKA发作在瑞典北方的医院集水区的所有成人患者被列入一项回顾性研究。结果1997 ~ 2000年，DKA年平均发病率为每10万成年居民5.9例。25例患者发生DKA，8例（32%）患有2型糖尿病，17例（68%）患有1型糖尿病。与1型糖尿病患者相比，2型糖尿病合并DKA患者年龄较大，C肽水平较高。在因DKA入院时，1型和2型患者中存在相似程度的高血糖症。与2型糖尿病患者相比，1型糖尿病患者的代谢性酸中毒更严重。在50%的2型糖尿病患者中，糖尿病被诊断在发作DKA.Conclusions DKA发生在高加索2型糖尿病患者在瑞典人口。虽然1型糖尿病患者中DKA的频率要高得多，但2型糖尿病可能占总DKA病例的三分之一。
Aims To determine the occurrence of diabetic ketoacidosis (DKA) in adult Type 2 and Type 1 diabetic patients in Northern Sweden and to determine whether DKA presents with a different clinical picture in Type 2 compared with Type 1 diabetic subjects.Methods All adult patients from a hospital catchment area in Northern Sweden with diagnosed DKA episodes during 1997-2000 were included in a retrospective study. Medical records and laboratory reports were analysed.Results During the years 1997 to 2000, the average annual incidence rate for DKA was 5.9 per 100 000 adult inhabitants. Twenty-five patients developed DKA, eight (32%) had Type 2 diabetes, while 17 (68%) had Type 1 diabetes. Type 2 diabetic patients with DKA were older and had higher levels of C-peptide than Type 1 diabetic patients. On admission because of DKA, a similar degree of hyperglycaemia was present in Type 1 and Type 2 patients. Metabolic acidosis was more severe in Type 1 compared with Type 2 diabetic patients. In 50% of the Type 2 diabetic patients, diabetes was diagnosed at the episode of DKA.Conclusions DKA occurs in Caucasian Type 2 diabetic patients within a Swedish population. Although the frequency of DKA is much higher in Type 1 diabetic patients, Type 2 diabetes may account for as much as one-third of the overall DKA cases.