Immunomodulatory effects of aged garlic extract
Immunomodulatory effects of aged garlic extract
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DOI：
10.1093/jn/131.3.1075s
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发表时间：
2001-03-01
影响因子：
4.2
通讯作者：
Itakura, Y
中科院分区：
文献类型：
--
作者：
Kyo, E;Uda, N;Itakura, Y
采用多种模型，研究了老化大蒜提取物（AGE）对免疫功能的影响。在免疫球蛋白（IG）E介导的过敏性小鼠模型中，AGE显著降低苦氯软膏致耳肿胀和静脉注射抗三硝基苯基抗体引起的抗原特异性耳肿胀。在移植瘤模型中，AGE对移植于小鼠体内的Sarcoma-180（异基因）和LL/2肺癌（同基因）细胞的生长有明显的抑制作用。同时，在给予AGE的荷肉瘤-180小鼠中观察到自然杀伤（NK）细胞和脾细胞杀伤活性增加。在心理应激模型中，AGE可显著预防电应激所致的脾脏重量下降，并恢复电应激所致的抗SRBC溶血空斑形成细胞的减少。这些研究强烈表明，AGE可能是一种很有前途的免疫调节剂，可以维持免疫功能的稳态;需要进一步研究以确定何时最有益。
Using various kinds of models, we examined the effects of aged garlic extract (AGE) on immune functions. In the immunoglobulin (Ig)E-mediated allergic mouse model, AGE significantly decreased the antigen-specific ear swelling induced by picryl chloride ointment to the ear and intravenous administration of antitrinitrophenyl antibody. In the transplanted carcinoma cell model, AGE significantly inhibited the growth of Sarcoma-180 (allogenic) and LL/2 lung carcinoma (syngenic) cells transplanted into mice. Concomitantly, increases in natural killer (NK) and killer activities of spleen cells were observed in Sarcoma-180-bearing mice administered AGE. In the psychological stress model, AGE significantly prevented the decrease in spleen weight and restored the reduction of anti-SRBC hemolytic plaque-forming cells caused by the electrical stress. These studies strongly suggest that AGE could be a promising candidate as an immune modifier, which maintains the homeostasis of immune functions; further studies are warranted to determine when it is most beneficial.