Effects of caloric restriction on gene expression in the arcuate nucleus
Effects of caloric restriction on gene expression in the arcuate nucleus
复制标题
热量限制对弓状核基因表达的影响
DOI：
10.1016/s0197-4580(02)00046-5
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发表时间：
2003
影响因子：
4.2
通讯作者：
Yoshiharu Yamaza
中科院分区：
文献类型：
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作者：
I. Shimokawa;T. Fukuyama;Kurumi Yanagihara;M. Tomita;Toshimitsu Komatsu;Y. Higami;Tomoshi Tuchiya;T. Chiba;Yoshiharu Yamaza
Neuroendocrine alterations that repress energy-costly physiologic processes such as reproduction and growth and induce stress responses, might underlie the antiaging effect of caloric restriction (CR). Neurons in the arcuate nucleus of the hypothalamus (ARH) might have a pivotal role in these neuroendocrine alterations. We investigated the effects of CR on gene expression of neuropeptide Y (NPY), proopiomelanocortin (POMC), growth hormone-releasing hormone (GHRH), somatostatin (SRIH), and cyclophilin (CP) in the ARH in male F344 rats at 6 months of age. Rats were fed ad libitum or a 30% caloric restricted diet with a modified alternate-days feeding regimen from 6 weeks of age. Reverse transcription-polymerase chain reaction (RT-PCR) methods were used to quantify mRNA levels over multiple time points during the 12-h/12-h dark/light cycle over a 2-days feeding cycle. The present study demonstrated that CR increased NPY-mRNA levels, but decreased POMC, GHRH, and CP mRNA levels differentially over the feeding cycle. The SRIH level was not significantly affected by CR. The present results support the neuroendocrine hypothesis of CR.
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下丘脑神经肽 Y、甘丙肽、阿片黑皮素原和脂肪细胞瘦素基因表达和分泌的每日变化：食物限制的影响。
DOI：
10.1210/endo.140.6.6789
发表时间：
1999
期刊：
Endocrinology.
影响因子：
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作者：
Xu,B;Kalra,PS;Farmerie,WG;Kalra,SP
通讯作者：
Kalra,SP
神经肽 Y 通过刺激生长抑素释放来抑制生长激素释放，具有显着的生理作用。
影响因子：
4.8
作者：
Rettori,V;Milenkovic,L;Aguila,MC;McCann,SM
通讯作者：
McCann,SM
适度的热量限制会改变生长抑素 mRNA 的亚细胞分布，并增加老年动物的生长激素脉冲幅度。
影响因子：
4.1
作者：
Sonntag,WE;Xu,X;Ingram,RL;D'Costa,A
通讯作者：
D'Costa,A
大鼠前促生长抑素的生物合成。
影响因子：
--
作者：
Goodman,RH;Montminy,MR;Low,MJ;Habener,JF
通讯作者：
Habener,JF