Temperature effects on life-history trade-offs, germline maintenance and mutation rate under simulated climate warming
Temperature effects on life-history trade-offs, germline maintenance and mutation rate under simulated climate warming
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DOI：
10.1098/rspb.2017.1721
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发表时间：
2017-11-15
影响因子：
4.7
通讯作者：
Arnqvist, Goran
中科院分区：
文献类型：
--
作者：
Berger, David;Stangberg, Josefine;Arnqvist, Goran
突变对进化过程有着根本性的影响，但进化过程如何塑造突变率仍然不太清楚。在无性单细胞生物中，在压力环境中观察到突变率增加，统治范式将这种增加归因于进化选择。然而，这一解释并不适用于有性繁殖的物种，因为人们对环境如何影响突变率知之甚少。在这里，我们挑战实验线的种子甲虫，在祖先的温度或模拟气候变暖下进化，修复诱导突变在祖先和压力的温度。结果表明，温度应激导致个体将更大的突变负荷传递给他们的孙辈。这表明，单细胞和多细胞生物中的应激诱导突变率可能是由于低条件个体的种系DNA修复受损而导致的。此外，适应模拟气候变暖的品系以繁殖为代价进化出了更长的寿命，这种分配决定改善了种系修复。这些结果表明，突变率可以调制的资源分配权衡，包括生活史性状和种系，并有重要的影响，适应和灭绝的速度，以及我们的理解在多细胞生物的遗传多样性。
Mutation has a fundamental influence over evolutionary processes, but how evolutionary processes shape mutation rate remains less clear. In asexual unicellular organism, increased mutation rates have been observed in stressful environments and the reigning paradigm ascribes this increase to selection for evolvability. However, this explanation does not apply in sexually reproducing species, where little is known about how the environment affects mutation rate. Here we challenged experimental lines of seed beetle, evolved at ancestral temperature or under simulated climate warming, to repair induced mutations at ancestral and stressful temperature. Results show that temperature stress causes individuals to pass on a greater mutation load to their grand-offspring. This suggests that stress-induced mutation rates, in unicellular and multicellular organisms alike, can result from compromised germline DNA repair in low condition individuals. Moreover, lines adapted to simulated climate warming had evolved increased longevity at the cost of reproduction, and this allocation decision improved germline repair. These results suggest that mutation rates can be modulated by resource allocation trade-offs encompassing life-history traits and the germline and have important implications for rates of adaptation and extinction as well as our understanding of genetic diversity in multicellular organisms.