RELATION BETWEEN ANTRAL MOTILITY AND GASTRIC-EMPTYING OF SOLIDS AND LIQUIDS IN HUMANS
RELATION BETWEEN ANTRAL MOTILITY AND GASTRIC-EMPTYING OF SOLIDS AND LIQUIDS IN HUMANS
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DOI：
10.1152/ajpgi.1985.249.5.g580
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发表时间：
1985-01-01
影响因子：
--
通讯作者：
ZINSMEISTER, AR
中科院分区：
文献类型：
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作者：
CAMILLERI, M;MALAGELADA, JR;ZINSMEISTER, AR
我们的目的是测试的假设，有一个胃窦相位压力活动和排空固体和液体从完整的人胃混合餐后的关系。这一假设进行了评估，在14个健康的人，我们进行了同步胃窦测压和放射性核素显像后摄取的膳食标记的[99mTc]硫胶体煮熟的鸡蛋（固体成分）和[111In]DTPA（液体成分）。数据分析包括对表达胃排空率和胃窦压力活动的不同模型的深入评价。我们发现，胃排空是充分代表了一个两相模型，包括滞后期和排空期，并通过幂指数模型的液相。远端胃窦运动的准确代表的斜率的累积胃窦运动指数。在固体滞后期间，胃窦运动与滞后的持续时间呈负相关。在固体排空期，固体排空与胃窦运动呈正相关。胃窦运动和总排空的液相餐之间没有显着的关系。然而，一个关系被发现时，胃窦运动与液体排空后，最初的固体滞后期。这些人类数据与胃窦压力活动在固体食物研磨中的作用以及胃窦在随后从胃推进固体和液体中的作用一致。
Our aim was to test the hypothesis that there is a relation between antral phasic pressure activity and the emptying of solids and liquids from the intact human stomach after a mixed meal. This hypothesis was evaluated in 14 healthy individuals in whom we performed simultaneous antral manometry and radioscintigraphy after ingestion of a meal labeled with [99mTc]sulfur colloid in cooked egg (solid component) and [111In]DTPA (liquid component). Analysis of the data included an in-depth evaluation of different models for expressing both gastric emptying rates and antral pressure activity. We found that gastric emptying was adequately represented by a two-phase model consisting of lag and emptying periods and by a power exponential model for the liquid phase. Distal antral motility was accurately represented by the slope of the cumulative antral motility index. During the lag period for solids, the antral motility was inversely related to the duration of the lag. During the solid-emptying period, there was a positive correlation between emptying of solids and antral motility. No significant relation was found between antral motility and overall emptying of the liquid phase of the meal. However, a relationship was found when antral motility was related to liquid emptying after an initial lag period for solids. These human data are consistent with a role of antral pressure activity in trituration of solid food and a role of the antrum in the subsequent propulsion of solids and liquids from the stomach.