Ionoacoustics for range monitoring of proton therapy
Ionoacoustics for range monitoring of proton therapy
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DOI：
10.1088/1742-6596/1154/1/012015
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发表时间：
2019-01
期刊：
影响因子：
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通讯作者：
S. Lehrack;W. Assmann;K. Parodi
中科院分区：
文献类型：
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作者：
S. Lehrack;W. Assmann;K. Parodi
与广泛建立的光子束相比，质子束在高度适形肿瘤剂量传递方面表现出良好的相互作用特性，更好地保护周围健康组织和关键结构。然而，这些优势的临床充分利用仍然受到治疗不确定性的阻碍，特别是与组织中质子的停止位置有关，决定了所谓的布拉格峰，质子释放大部分能量。因此，目前正在研究几种方法，以实现对患者体内质子束范围的理想实时验证。虽然大多数考虑的技术旨在利用核相互作用产生的二次发射，但人们对利用组织中离子相互作用产生的声发射的替代、经济有效的解决方案重新产生了兴趣。因此，这一贡献将解决临床前和临床光束能量的所谓“离子声学”的基础和最近的实验。
Proton beams exhibit favourable interaction properties for highly conformal tumour dose delivery with better sparing of surrounding healthy tissue and critical structures in comparison to widely established photon beams. However, full clinical exploitation of these advantages is still hampered by treatment uncertainties, particularly related to the stopping position of protons in tissue, determining the so called Bragg peak, where protons release most of their energy. Hence, several approaches are currently investigated to enable an in-vivo, ideally real-time verification of the proton beam range in the patient. While most of the considered techniques aim at exploiting secondary emissions from nuclear interactions, interest is being regained for alternative, cost-effective solutions exploiting acoustic emissions originating from ion interaction in tissue. This contribution will thus address the basics and recent experiments of this so called “ionoacoustics” for pre-clinical and clinical beam energies.