RNA splicing: What has phosphorylation got to do with it?
RNA splicing: What has phosphorylation got to do with it?
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DOI：
10.1016/s0960-9822(99)80128-6
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发表时间：
1999-03-25
期刊：
影响因子：
9.2
通讯作者：
Misteli, T
中科院分区：
文献类型：
--
作者：
Misteli, T
许多前体mRNA剪接因子在体内被磷酸化，但这种修饰的作用尚不清楚。最近的观察表明，磷酸化调节剪接体内的蛋白质-蛋白质相互作用，从而有助于剪接过程中剪接体的动态结构重组。
Many pre-mRNA splicing factors are phosphorylated in vivo, but the role of this modification has been unclear. Recent observations suggest that phosphorylation modulates protein-protein interactions within the spliceosome, thereby contributing to dynamic structural reorganization of the spliceosome during splicing.