Current development of biodegradable polymeric materials for biomedical applications.
Current development of biodegradable polymeric materials for biomedical applications.
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DOI：
10.2147/dddt.s165440
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Zheng Z
中科院分区：
文献类型：
--
作者：
Song R;Murphy M;Li C;Ting K;Soo C;Zheng Z
在过去的半个世纪里，用于生物医学应用的可生物降解聚合物材料的发展取得了显著进展。可生物降解聚合物材料在治疗器械的开发中备受青睐，包括用于组织工程的临时植入物和三维支架。在将可生物降解聚合物材料用于药理学应用方面也取得了进一步的进展，例如用于控制/持续药物释放的给药载体。这些应用要求材料具有特定的物理化学、生物学和降解特性，以实现有效的治疗。因此，各种各样能够发生水解或酶促降解的天然或合成聚合物正在被研究用于生物医学应用。这篇综述概述了用于各种生物医学应用（包括组织工程、临时植入物、伤口愈合和药物递送）的可生物降解天然和合成聚合物材料的当前发展情况。
In the last half-century, the development of biodegradable polymeric materials for biomedical applications has advanced significantly. Biodegradable polymeric materials are favored in the development of therapeutic devices, including temporary implants and three-dimensional scaffolds for tissue engineering. Further advancements have occurred in the utilization of biodegradable polymeric materials for pharmacological applications such as delivery vehicles for controlled/sustained drug release. These applications require particular physicochemical, biological, and degradation properties of the materials to deliver effective therapy. As a result, a wide range of natural or synthetic polymers able to undergo hydrolytic or enzymatic degradation is being studied for biomedical applications. This review outlines the current development of biodegradable natural and synthetic polymeric materials for various biomedical applications, including tissue engineering, temporary implants, wound healing, and drug delivery.