Treatment results of 165 pediatric patients with non-metastatic nasopharyngeal carcinoma: A Rare Cancer Network study
Treatment results of 165 pediatric patients with non-metastatic nasopharyngeal carcinoma: A Rare Cancer Network study
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DOI：
10.1016/j.radonc.2006.08.019
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发表时间：
2006-10-01
影响因子：
5.7
通讯作者：
Atahan, Ibtisam Lale
中科院分区：
文献类型：
--
作者：
Ozyar, Enis;Selek, Ugur;Atahan, Ibtisam Lale
目的：这罕见的癌症网络（RCN）的研究进行了儿科鼻咽癌（PNPC）患者的最佳剂量的放射治疗，并确定预后factors.Patients和方法：该研究包括165例诊断PNPC治疗1978年和2003年之间。中位年龄为14岁。有3例（1.8%）患者为I期，1例（0.6%）为IIA期，10例（6.1%）为IIB期，60例（36.4%）为III期，44例（26.7%）为IVA期，47例（29%）为IVB期。而21（12.7%）患者仅接受放疗（RT）治疗，144结果：全组5年总生存率为77.4%（12/16），平均随访时间为48个月，平均随访时间为48个月（95%CI：70.06-84.72），而5年无病生存率（DFS）为68.8%（95%CI：61.33-76.31）。多因素分析中，年龄> 14岁为LRC的不利因素（p = 0.04）; DMFS的配偶性别（p = 0.03）; LRFS的T3/T4疾病（p = 0.01）;和DFS的N3疾病（p = 0.002）和OS（p = 0.002）; LRFS的EBRT剂量小于66戈伊（p = 0.02）和LRRFS（p = 0.0028）;以及仅接受RT治疗LRFS的患者结论：我们的结果支持目前采用放疗和化疗联合治疗鼻咽癌的最佳实践。然而，鉴于儿科患者相对有利的预后和长寿潜力，应鼓励研究以减少其长期后遗症的可能性。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Purpose: This Rare Cancer Network (RCN) study was performed in pediatric nasopharyngeal carcinoma (PNPC) patients to evaluate the optimal dose of radiotherapy and to determine prognostic factors.Patients and Methods: The study included 165 patients with the diagnosis of PNPC treated between 1978 and 2003. The median age was 14 years. There were 3 (1.8%) patients with stage I, 1 (0.6%) with IIA, 10 (6.1%) with IIB, 60 (36.4%) with III, 44 (26.7%) with IVA, and 47 (29%) with IVB disease. While 21 (12.7%) patients were treated with radiotherapy (RT) alone, 144 (87.3%) received chemotherapy and RT. The median follow-up time was 48 months.Results: The actuarial 5-year overall survival (OS) was 77.4% (95% CI: 70.06-84.72), whereas the actuarial 5-year disease-free survival (DFS) rate was 68.8% (95% CI: 61.33-76.31). In multivariate analysis, unfavorable factors were age > 14 years for LRC (p = 0.04); mate gender for DMFS (p = 0.03); T3/T4 disease for LRFS (p = 0.01); and N3 disease for DFS (p = 0.002) and OS (p = 0.002); EBRT dose of less than 66 Gy for LRFS (p = 0.02) and LRRFS (p = 0.0028); and patients treated with RT alone for LRFS (p = 0.0001), LRRFS (p = 0.007) and DFS (p = 0.02).Conclusion: Our results support the current practice of using combined radiation and chemotherapy for optimal treatment of NPC. However, research should be encouraged in an attempt to reduce the potential for long-term sequelae in pediatric patients given their relatively favorable prognosis and potential for longevity. (c) 2006 Elsevier Ireland Ltd. All rights reserved.