Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials
Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials
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DOI：
10.1136/ard.2010.139550
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发表时间：
2011-03-01
影响因子：
27.4
通讯作者：
Tak, Paul P.
中科院分区：
文献类型：
--
作者：
van de Sande, Marleen G. H.;Gerlag, Danielle M.;Tak, Paul P.
滑膜炎症是类风湿性关节炎(RA)的特征之一。滑膜组织的分析增加了我们对RA发病机制的了解，有助于确定潜在的治疗靶点，并已用于抗风湿治疗的反应和机制评估。此外，正在进行研究，目的是确定滑膜中的诊断和预后生物标记物。本文概述了目前使用的滑膜组织采样和处理程序，并提出了支持多中心翻译研究的标准化建议。
Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial tissue has increased our understanding of RA pathogenesis, aided in identifying potential therapeutic targets and has been used in the response and mechanistic evaluation of antirheumatic treatments. In addition, studies are ongoing, aimed at the identification of diagnostic and prognostic biomarkers in the synovium. This paper outlines the currently used procedures for sampling and processing of synovial tissue, and presents a standardised recommendation to support multicentre translational research.