Hyperleptinemia: Relationship to adiposity and insulin resistance in the spontaneously obese rhesus monkey
Hyperleptinemia: Relationship to adiposity and insulin resistance in the spontaneously obese rhesus monkey
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DOI：
10.1055/s-2007-979876
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发表时间：
1996-12-01
影响因子：
2.2
通讯作者：
Hansen, BC
中科院分区：
文献类型：
--
作者：
Bodkin, NL;Nicolson, M;Hansen, BC
测定了正常体重和自发性肥胖雄性恒河猴的血浆瘦素水平，以及循环瘦素与β细胞基础分泌、葡萄糖刺激反应性和外周胰岛素敏感性的关系。正常瘦猴的基础瘦素平均值为6.0 +/- 1.3 ng/ml，肥胖猴的平均值为22.6 +/- 2.9 ng/ml。在所有猴子中，血浆瘦素浓度与体重、体脂、空腹血浆胰岛素、对静脉葡萄糖的急性胰岛素反应和外周胰岛素敏感性显著相关，但与空腹血糖或糖耐量无关。体脂和血浆胰岛素浓度是循环瘦素水平的最佳预测因子（R（2）= 62.6%），与外周胰岛素敏感性无关。17只肥胖猴子中有4只的血浆瘦素浓度在正常范围内，这一发现可能与肥胖的异质性有关。血浆瘦素与体脂和血浆胰岛素（基础和葡萄糖刺激）的密切相关支持瘦素在肥胖和β细胞分泌过多之间的联系中发挥作用的可能性。然而，瘦素在外周胰岛素抵抗、高血压和2型糖尿病发生发展中的潜在作用还需要进一步研究。
Plasma leptin levels in normal-weight and spontaneously obese male rhesus monkeys, and the relationships of circulating leptin to beta-cell basal secretion, glucose-stimulated responsiveness and peripheral insulin sensitivity, were determined. Basal leptin in normal lean adult monkeys averaged 6.0 +/- 1.3 ng/ml and in the obese monkeys averaged 22.6 +/- 2.9 ng/ml. In all monkeys, plasma leptin concentration was significantly related to body weight, body fat, fasting plasma insulin, acute insulin response to intravenous glucose, and peripheral insulin sensitivity but not to fasting glucose or glucose tolerance. Body fat and plasma insulin concentration were the best predictors of circulating leptin levels (R(2) = 62.6%) independent of peripheral insulin sensitivity. Four of 17 obese monkeys had plasma leptin concentrations in the normal range, a finding that may be related to the heterogeneity of obesity. The close association of plasma leptin to body fat and plasma insulin (both basal and glucose-stimulated) support the possibility of a role of leptin in the link between obesity and beta-cell hypersecretion. However, the potential role of leptin in the development of peripheral insulin resistance, hyerglycemia and type 2 diabetes will require further study.