A STUDY OF CHEMICAL CARCINOGENESIS .46. COMPARATIVE TUMOR INITIATING ACTIVITY ON MOUSE SKIN OF 6-NITROBENZO[A]PYRENE, 6-NITROCHRYSENE, 3-NITROPERYLENE, 1-NITROPYRENE AND THEIR PARENT HYDROCARBONS
A STUDY OF CHEMICAL CARCINOGENESIS .46. COMPARATIVE TUMOR INITIATING ACTIVITY ON MOUSE SKIN OF 6-NITROBENZO[A]PYRENE, 6-NITROCHRYSENE, 3-NITROPERYLENE, 1-NITROPYRENE AND THEIR PARENT HYDROCARBONS
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DOI：
10.1016/0304-3835(82)90015-5
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发表时间：
1982-01-01
期刊：
影响因子：
9.7
通讯作者：
HOFFMANN, D
中科院分区：
文献类型：
--
作者：
ELBAYOUMY, K;HECHT, SS;HOFFMANN, D
在十四烷酰佛波醇乙酸酯的促进下，测试了 6-硝基苯并[a]芘、6-硝基芘、3-硝基苝、1-硝基芘和相应的母体烃[苯并(a)芘、苝、苝、芘]在小鼠皮肤上的肿瘤引发活性。 6-硝基苯并[a]芘和苯并[a]芘的起始剂量各为0.05 mg；对于所有其他化合物，起始剂量为 1.0 mg。 6-硝基在 60% 的小鼠中诱发肿瘤（2.1 个肿瘤/小鼠），但致瘤性明显低于 6-硝基。 3-硝基苝在 42% 的小鼠中诱导肿瘤（0.5 个肿瘤/小鼠），并且明显比苝更活跃。 1-硝基芘和6-硝基苯并[a]芘在测试浓度下均未表现出显着的致瘤活性。
6-Nitrobenzo[a]pyrene, 6-nitrochrysene, 3-nitroperylene, 1-nitropyrene and the corresponding parent hydrocarbons [benzo(a)pyrene, chrysene, perylene, pyrene] were tested for tumor initiating activity on mouse skin with promotion by tetradecanoylphorbol acetate. The initiating doses of 6-nitrobenzo[a]pyrene and benzo[a]pyrene were 0.05 mg each; for all other compounds the initiating doses were 1.0 mg. 6-Nitrochrysene induced tumors in 60% of the mice (2.1 tumors/mouse), but was significantly less tumorigenic than chrysene. 3-Nitroperylene induced tumors in 42% of the mice (0.5 tumors/mouse) and was significantly more active than perylene. Neither 1-nitropyrene nor 6-nitrobenzo[a]pyrene exhibited significant tumorigenic activity in the concentrations tested.