ANTITUMOR-ACTIVITY OF MURINE TUMOR NECROSIS FACTOR (TNF) AGAINST TRANSPLANTED MURINE TUMORS AND HETEROTRANSPLANTED HUMAN-TUMORS IN NUDE-MICE
ANTITUMOR-ACTIVITY OF MURINE TUMOR NECROSIS FACTOR (TNF) AGAINST TRANSPLANTED MURINE TUMORS AND HETEROTRANSPLANTED HUMAN-TUMORS IN NUDE-MICE
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DOI：
10.1002/ijc.2910340219
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发表时间：
1984-01-01
影响因子：
6.4
通讯作者：
SAKURAI, A
中科院分区：
文献类型：
--
作者：
HARANAKA, K;SATOMI, N;SAKURAI, A
以8种小鼠肿瘤和5种人肿瘤为实验材料，研究了高纯度肿瘤坏死因子对裸鼠移植瘤的抑制作用。小鼠静脉注射给药。或肿瘤内注射肿瘤坏死因子，当肿瘤完全建立时开始。肿瘤坏死因子对小鼠和人的各种肿瘤均有良好的疗效。移植到小鼠体内的Meth A肉瘤、结肠26、Ehrlich、肉瘤180、MM 46、MH 134、B16黑色素瘤和Lewis肺癌均出现肿瘤坏死和消退。有时在Meth A肉瘤、S180肉瘤、Ehrlich和MM46肿瘤中观察到完全治愈。人类癌症，Seki，HMV-I，Kato-III，MKN 45，或KB，异种移植到裸鼠体内，在几次肿瘤内注射肿瘤坏死和大小缩小。在BALB/c nu/+小鼠和BALB/c nu/nu小鼠移植瘤中，观察到肿瘤坏死因子对Meth A肉瘤的疗效有显著差异。给药对BALB/c nu/+小鼠的作用强于nu/nu小鼠。相反，瘤内给药后，nu/+和nu/nu小鼠的肿瘤坏死几乎相同。小鼠来源的肿瘤坏死因子不仅对小鼠肿瘤具有抗肿瘤活性，而且对人肿瘤也具有抗肿瘤活性。除了对肿瘤细胞的直接杀伤作用外，肿瘤坏死因子还诱导了一种宿主介导的因子，从而发挥了抗肿瘤作用。
The antitumor activity of highly purified tumor necrosis factor (TNF) was tested against 8 kinds of murine tumor and 5 kinds of human tumor heterotransplanted into nude mice. Mice were treated by i.v. or intratumoral injection of TNF, commencing when the tumors were well established. TNF showed an excellent curative effect against all kinds of murine and human tumors tested. Meth A sarcoma, Colon 26, Ehrlich, sarcoma 180, MM 46, MH 134, B16 melanoma, and Lewis lung tumors transplanted into mice underwent tumor necrosis and regression following a single injection of TNF. Sometimes a complete cure was observed in Meth A sarcoma, sarcoma 180, Ehrlich, and MM 46 tumors. Human cancers, SEKI, HMV-I, KATO-III, MKN 45, or KB, heterotransplanted into nude mice, also exhibited tumor necrosis and regression in size following several intratumoral injections of TNF. A great difference in curative effects of TNF was observed in Meth A sarcomas between those transplanted into BALB/c nu/+ and into BALB/c nu/nu mice; following a single i.v. administration the effect was stronger in BALB/c nu/+ than in nu/nu mice. In contrast, tumor necrosis was almost the same in nu/+ and nu/nu mice following intratumoral administration. TNF from mice had an antitumor activity against not only murine tumors but also human tumors. In addition to direct cytotoxicity against tumor cells, TNF induced a host-mediated factor which contributed to the antitumor effects.