Circulating Betatrophin Correlates with Triglycerides and Postprandial Glucose among Different Glucose Tolerance Statuses--A Case-Control Study.
Circulating Betatrophin Correlates with Triglycerides and Postprandial Glucose among Different Glucose Tolerance Statuses--A Case-Control Study.
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DOI：
10.1371/journal.pone.0133640
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Yu X
中科院分区：
文献类型：
--
作者：
Gao T;Jin K;Chen P;Jin H;Yang L;Xie X;Yang M;Hu C;Yu X
以往关于betatrophin对胰岛素抵抗状态下糖脂代谢的研究得出了有争议的结论。为了进一步确定betatrophin的可能影响，我们测量了新诊断的2型糖尿病（T2 DM）患者以及糖耐量受损（IGT）和正常糖耐量（NGT）受试者的循环betatrophin水平，并研究了这些具有不同糖耐量状态的患者的血清betatrophin与其他临床参数之间的关系。共招募了460名年龄在40-60岁之间的奉贤区常住居民。根据75 g口服葡萄糖耐量试验结果，我们根据年龄、性别和体重指数（18-28 kg/m2）选择了新诊断的T2 DM患者（n = 50）和IGT（n = 51）和NGT（n = 50）受试者。测量人体测量参数、糖化血红蛋白、血脂和空腹胰岛素。通过ELISA测定血清betatrophin浓度。2型糖尿病患者血清betatrophin水平显著高于IGT和NGT组，胰岛β细胞功能较好者血清betatrophin水平显著低于IGT和NGT组。校正年龄、性别和体重指数后，所有受试者的血清betatrophin与甘油三酯、餐后2小时血糖、丙氨酸氨基转移酶和天冬氨酸氨基转移酶呈正相关。多元回归分析显示餐后2小时血糖与血清betatrophin显著独立相关。在新诊断的T2 DM患者中，循环betatrophin增加，并与甘油三酯和餐后血糖水平呈正相关。结果表明，betatrophin可能参与葡萄糖和甘油三酯代谢。
Previous researches of betatrophin on glucose and lipids metabolism under insulin-resistant condition have reached controversial conclusions. To further identify the possible impact of betatrophin, we measured the circulating betatrophin levels in newly diagnosed type 2 diabetes (T2DM) patients, and in subjects with both impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) and investigated the relationship between serum betatrophin and other clinical parameters in these patients with different glucose tolerance statuses. A total of 460 permanent residents of the Fengxian District, aged 40–60 years, were enrolled. Based on the results of a 75 g oral glucose tolerance test, we selected newly diagnosed T2DM (n = 50) patients and subjects with IGT (n = 51) and NGT (n = 50) according to their age, gender and body mass index (18–28 kg/m2). Anthropometric parameters, glycosylated haemoglobin, blood lipids and fasting insulin were measured. Serum betatrophin concentrations were determined via ELISA. Serum betatrophin levels in T2DM patients were increased significantly compared with IGT and NGT groups, and decreased in subjects with better islet beta cell function. Serum betatrophin was positively correlated with triglyceride, 2-hour postprandial glucose, alanine aminotransferase and aspartate transaminase after adjusting for age, sex and body mass index in all subjects. Multiple regression analysis showed that 2-hour postprandial glucose was independently associated with serum betatrophin significantly. Circulating betatrophin is increased in newly-diagnosed T2DM patients and positively correlated with the triglycerides and postprandial glucose levels. The results suggest that betatrophin may participate in glucose and triglycerides metabolism.