Higher serum Tenascin-C levels reflect the severity of heart failure, left ventricular dysfunction and remodeling in patients with dilated cardiomyopathy
Higher serum Tenascin-C levels reflect the severity of heart failure, left ventricular dysfunction and remodeling in patients with dilated cardiomyopathy
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DOI：
10.1253/circj.71.327
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发表时间：
2007-03-01
影响因子：
3.3
通讯作者：
Kitabatake, Akira
中科院分区：
文献类型：
--
作者：
Terasaki, Fumio;Okamoto, Hiroshi;Kitabatake, Akira
腱生蛋白-C（Tenascin-C，TN-C）是一种细胞外基质糖蛋白，在胚胎发育过程中特异性高水平表达，但在成人心脏中不表达。TN-C在各种病理条件下，如急性心肌梗死、急性心肌炎和某些心肌病病例，在炎症组织重塑或伤口愈合部位再次出现。因此，TN-C的表达可能有助于检测扩张型心肌病（DCM）的临床特征和心室重构。2方法与结果采用酶联免疫吸附法（ELISA）测定107例扩张型心肌病（DCM）患者血清TN-C水平。临床数据也通过Pearson或斯皮尔曼相关分析进行评估，以估计变量之间的相关性。DCM患者血清TN-C水平明显高于正常对照组（P < 0.001）。TNC水平与纽约心脏协会心功能分级呈显著正相关（p < 0.001），B型利钠肽水平（p < 0.001），胸部X线片上的心胸比率左室舒张末期内径（P < 0.01）（p < 0.05）和左室收缩末期内径（P < 0.01），与左室射血分数呈显著负相关结论扩张型心肌病患者血清TN-C水平升高，提示其心力衰竭、左室功能不全及心肌重构的严重程度。
Background Tenascin-C (TN-C), an extracellular matrix glycoprotein, is specifically expressed at high levels during embryonic development, but not in the adult heart. TN-C reappears at sites of inflammatory tissue remodeling or wound healing under various pathologic conditions, such as acute myocardial infarction, acute myocarditis, and some cases of cardiomyopathy. Therefore, the expression of TN-C might be useful for detecting the clinical characteristics of, and ventricular remodeling in, dilated cardiomyopathy (DCM). \ Methods and Results Circulating serum TN-C levels in 107 patients with DCM were measured using an ELISA kit. Clinical data were also assessed by Pearson's or Spearman's correlation analysis to estimate correlations between variables. Serum TN-C levels in DCM patients were higher than those in normal controls (p < 0.001). TNC levels showed a significantly positive con-elation with New York Heart Association functional class (p < 0.001), B-type natriuretic peptide level (p < 0.001), cardiothoracic ratio on chest X-ray (p < 0.01), left ventricular end-diastolic diameter (p < 0.05) and left ventricular end-systolic diameter (p < 0.01), and a significantly negative correlation with left ventricular ejection fraction (p < 0.01).Conclusions The findings suggest that increased serum TN-C levels indicate the severity of heart failure, left ventricular dysfunction and remodeling in patients with DCM.