Current topics of physiology and pharmacology in the lymphatic system
Current topics of physiology and pharmacology in the lymphatic system
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DOI：
10.1016/j.pharmthera.2004.10.009
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发表时间：
2005-02-01
影响因子：
13.5
通讯作者：
Kawai, Y
中科院分区：
文献类型：
--
作者：
Ohhashi, T;Mizuno, R;Kawai, Y
本文综述了集合淋巴管节律性自发收缩的生理意义。其在淋巴运输中起关键作用，并且似乎通过改变淋巴管的节律性收缩和收缩模式的起搏点来控制淋巴形成。一个特征性的功能，节律泵活动的工作在体内生理的特定环境下的较低的氧张力在淋巴（25-40毫米汞柱）进行了评估。具有典型的特征。综述了淋巴管内皮细胞产生内源性一氧化氮（NO）和/或激活ATP敏感性钾通道（K-ATP）在生理或病理生理条件下调节淋巴转运中的重要作用。恶性肿瘤细胞释放的化学物质和肿瘤源性甲状旁腺素相关肽（PTHr-P）也显示通过产生内源性NO和激活K-ATP通道导致淋巴泵活性显著降低。终于来了讨论了淋巴液氧分压降低的生理意义和作用。产生内源性NO和激活淋巴形成中的K-ATP。淋巴转运和淋巴结的功能。(C)2004年爱思唯尔公司All rights reserved.
We have reviewed physiological significance of rhythmical spontaneous contractions of collecting lymph vessels. which play a pivotal role in lymph transport and seem to control lymph formation through changing the pacemaker sites of the rhythmic contractions and contractile patterns of the lymphangions. A characteristic feature that the rhythmic pump activity works in vivo physiologically under the specific environment of lower oxygen tension in lymph (25-40 mm Hg) has been evaluated. With the characteristic feature. generation of endogenous nitric oxide (NO) from lymphatic endothelial cells and/or activation of ATP-sensitive potassium channels (K-ATP) are reviewed to play crucial roles in the regulation of lymph transport at physiological or pathophysiological conditions. Chemical substances released front malignant tumor cells and tumor-derived parathyroid hormone-related peptide (PTHr-P) are also shown to cause a significant reduction of lymphatic pump activity through generation of endogenous NO and activation of K-ATP channels. Finally. we have discussed physiological significance and roles of the lower oxygen tension in lymph. generation of endogenous NO. and activation of K-ATP in lymph formation. lymph transport, and the functions of lymph nodes. (C) 2004 Elsevier Inc. All rights reserved.