Liver and kidney toxicity induced by Afzal smokeless tobacco product in Oman
Liver and kidney toxicity induced by Afzal smokeless tobacco product in Oman
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DOI：
10.1016/j.tice.2017.01.008
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发表时间：
2017-04-01
期刊：
影响因子：
2.6
通讯作者：
Al-Adawi, Kawthar
中科院分区：
文献类型：
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作者：
Al-Mukhaini, Nawal;Ba-Omar, Taher;Al-Adawi, Kawthar
阿夫扎尔是阿曼常见的无烟烟草产品（STP），据信含有可能损害肝脏和肾脏等某些器官功能的毒素。将 Afzal 的水提取物添加到饮用水中，给体重分别为 60-80 g 和 150-240 g 的年轻和成年 Wistar 白化大鼠 (n=72) 口服给药 8 周。将动物分为三组：对照组（用蒸馏水代替 Afzal 提取物）、低剂量组（3 毫克尼古丁/公斤体重/天）和高剂量组（6 毫克尼古丁/公斤体重/天）。对动物实施安乐死，并收集它们的血液、肝脏和肾脏用于生化和组织病理学研究。检测肝功能时检测丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST），检测肾功能时检测血尿素氮（BUN）和肌酐（CRT）。结果显示 ALT、AST、BUN 和 CRT 水平显着升高（P
Afzal, the common smokeless tobacco product (STP) in Oman, is believed to contain toxins that may impair the function of some organs such as liver and kidney. An aqueous extract from Afzal was added to drinking water to be administrated orally to Wistar albino rats (n=72) young and adult from both genders weighing between 60-80 g and 150-240 g respectively for 8 weeks. Animals were divided into three groups: control (distilled water instead of Afzal extract), low-dose (3 mg nicotine/kg body weight/day) and high-dose (6 mg nicotine/kg body weight/day). The animals were euthanized and their blood, liver and kidney were collected for biochemical and histopathological investigations. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were assayed for the liver function, while blood urea nitrogen (BUN) and creatinine (CRT) were assayed for the kidney function. The results showed a significant increase in the ALT, AST, BUN and CRT levels (P