Regular Exercise in Drosophila Prevents Age-Related Cardiac Dysfunction Caused by High Fat and Heart-Specific Knockdown of skd.
Regular Exercise in Drosophila Prevents Age-Related Cardiac Dysfunction Caused by High Fat and Heart-Specific Knockdown of skd.
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DOI：
10.3390/ijms24021216
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发表时间：
2023-01-07
影响因子：
5.6
通讯作者：
Zheng, Lan
中科院分区：
文献类型：
--
作者：
Cao, Yurou;He, Shiyi;Ding, Meng;Gu, Wenzhi;Wang, Tongquan;Zhang, Shihu;Feng, Jiadong;Li, Qiufang;Zheng, Lan
Skuld（skd）是介体复合物亚单位复合物的亚单位。在心脏中，skd控制全身肥胖，参与全身能量代谢，并与心脏功能和衰老密切相关。但心脏skd对心脏能量代谢的影响是否影响心脏功能尚不清楚。我们发现，心脏特异性敲低skd显示心脏功能受损、代谢障碍和过早衰老。对果蝇进行运动和高脂饮食（HFD）干预，以探讨运动对HFD果蝇心脏skd表达和心功能的影响。我们发现Hand-Gal 4>skd RNAi（KC）果蝇具有受损的心脏功能、代谢障碍和过早衰老。规律运动能显著改善HFD KC果蝇的心功能和代谢，延缓衰老。因此，我们的研究发现skd对心脏能量代谢的影响影响心脏功能。运动可以抵消由HFD和心脏特异性敲低skd引起的年龄相关的心功能不全和代谢紊乱。Skd可能是心脏病潜在的治疗靶点。
Skuld (skd) is a subunit of the Mediator complex subunit complex. In the heart, skd controls systemic obesity, is involved in systemic energy metabolism, and is closely linked to cardiac function and aging. However, it is unclear whether the effect of cardiac skd on cardiac energy metabolism affects cardiac function. We found that cardiac-specific knockdown of skd showed impaired cardiac function, metabolic impairment, and premature aging. Drosophila was subjected to an exercise and high-fat diet (HFD) intervention to explore the effects of exercise on cardiac skd expression and cardiac function in HFD Drosophila. We found that Hand-Gal4>skd RNAi (KC) Drosophila had impaired cardiac function, metabolic impairment, and premature aging. Regular exercise significantly improved cardiac function and metabolism and delayed aging in HFD KC Drosophila. Thus, our study found that the effect of skd on cardiac energy metabolism in the heart affected cardiac function. Exercise may counteract age-related cardiac dysfunction and metabolic disturbances caused by HFD and heart-specific knockdown of skd. Skd may be a potential therapeutic target for heart disease.
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