A new device for delivering drugs into the inner ear: Otoendoscope with microcatheter
A new device for delivering drugs into the inner ear: Otoendoscope with microcatheter
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DOI：
10.1016/j.anl.2011.04.006
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发表时间：
2012-04-01
影响因子：
1.7
通讯作者：
Ogawa, Kaoru
中科院分区：
文献类型：
--
作者：
Kanzaki, Sho;Saito, Hideyuki;Ogawa, Kaoru
目的：鼓室内药物注射(ITI)是一种很有吸引力的治疗方法。然而，如果圆形窗膜(RWM)无法显示，则需要首先去除粘连，然后才能进行ITI。我们研制并测试了一种用于ITI的新型耳内窥镜装置，该装置可以显示RWM。方法：我们的耳内窥镜由一个用于给药的导管通道和一个吸引道组成。结果：用于内耳给药的新型耳内窥镜有一个带导管的细针，可以用来取出或穿孔圆形窗龛(RWN)黏膜粘连。结论：我们研制的耳内窥镜可用于将药物直接应用于RWM表面，并验证内耳给药系统的正确放置，确保其安全到位。(C)2011爱思唯尔爱尔兰有限公司。保留所有权利。
Objectives: Intratympanic injection (ITI) of drugs into the inner ear is an attractive way to deliver therapy. However, if the round window membrane (RWM) cannot be visualized, adhesions need to be removed first before ITI can be performed. We developed and tested a novel otoendoscopy device that allows visualization of the RWM for the purpose of ITI.Methods: Our otoendoscope consists of a catheter channel for delivering drugs and a suction channel.Results: The novel otoendoscope for inner ear drug delivery has a fine needle with catheter, which can be used to remove or perforate round window niche (RWN) mucosal adhesions. The elliptical shape of the otoendoscope effectively captures the field in the light-guided area, resulting in bright images.Conclusions: Our otoendoscope can be used to apply drugs directly onto the surface of the RWM and to verify the correct placement of an inner ear drug delivery system, ensuring that it is safely in place. (C) 2011 Elsevier Ireland Ltd. All rights reserved.