Vitamin D Is Inversely Related to Obesity: Cross-Sectional Study in a Small Cohort of Serbian Adults
Vitamin D Is Inversely Related to Obesity: Cross-Sectional Study in a Small Cohort of Serbian Adults
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DOI：
10.1080/07315724.2018.1538828
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发表时间：
2019-07-04
影响因子：
3.5
通讯作者：
Glibetic, Maria
中科院分区：
文献类型：
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作者：
Pantovic, Ana;Zec, Manja;Glibetic, Maria
目的：维生素 D (vitD) 还可调节骨骼健康和矿化以外的多种健康状况。它在心脏代谢状况中的作用仍不确定。方法：我们对 87 名表面健康的塞尔维亚成年人进行了一项横断面研究。我们评估了他们的饮食摄入量、人体测量和生化参数、血压和维生素 D 状态（血清 25-羟基维生素 D、25(OH)D）。没想到一月的状态明显比七月高。因此，我们汇集了两个时间点的数据，以增强进行关联分析的统计能力。我们采用线性回归模型来评估 vitD 状态与血脂和血压等肥胖生物标志物之间的关联。结果：该队列中的平均 vitD 摄入量为 3.85 +/- 4.71 μg，低于推荐值。合并队列中的受试者中，60.58% 缺乏 vitD（血清 25(OH)D 低于 50 nmol/L），其中大多数是超重女性。在粗回归模型中，维生素 D 状态往往与体脂百分比和腰围/身高比成反比。调整年龄和性别后，该状态与腰围、腰高比、腰臀比显着相关（β=-0.116，95%置信区间[CI]：-0.206，-0.025，β=-0.001，95%CI：-0.001，0.000，β=-0.001，95%CI：-0.001， 0.000, 分别）。这些关联仅存在于女性内部。完全调整的模型支持 vitD 与中心性肥胖独立相关的概念，无论年龄、性别和总体肥胖如何。结论：在 vitD 摄入量较低的表面健康成年人中，vitD 状态与肥胖参数呈负相关，尤其是在女性中。我们的数据支持制定和实施增加维生素 D 摄入量的公共卫生政策的必要性，并将其作为肥胖管理策略的一部分。
Objective: Vitamin D (vitD) mediates numerous health conditions other than bone health and mineralization. Its role in cardiometabolic condition is still inconclusive. Methods: We conducted a cross-sectional study in 87 apparently healthy Serbian adults. We assessed their dietary intake, anthropometric and biochemical parameters, blood pressure, and vitD status (as serum 25-hydroxyvitamin D, 25(OH)D). Unexpectedly, the status was significantly higher in January than in July. Therefore, we pooled the data from two time points, to enhance the statistical power for carrying out association analyses. We employed linear regression models to evaluate the associations between vitD status and the obesity biomarkers of serum lipids and blood pressure. Results: Mean vitD intake of 3.85 +/- 4.71 mu g in the cohort was below recommended. Of the subjects in the pooled cohort, 60.58% were vitD deficient (with serum 25(OH)D below 50 nmol/L), with the majority of them being women who were overweight. VitD status tended to be inversely related to percent body fat and waist/height ratio in the crude regression model. After age and gender adjustment, the status was significantly related to waist circumference, waist/height ratio, and waist/hip ratio (beta = -0.116, 95% confidence interval [CI]: -0.206, -0.025, beta = -0.001, 95% CI: -0.001, 0.000, and beta = -0.001, 95% CI: -0.001, 0.000, respectively). These associations remained only within women. Fully adjusted models supported the notion of vitD being independently associated with central adiposity, regardless of age, gender, and total obesity. Conclusions: In apparently healthy adults with low vitD intake, vitD status was inversely associated with obesity parameters, pronouncedly in women. Our data support the need for development and implementation of public health policies on increasing vitD intake also as part of obesity management strategies.