DNA damage checkpoint inactivation: Adaptation and recovery
DNA damage checkpoint inactivation: Adaptation and recovery
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DOI：
10.1016/j.dnarep.2009.04.008
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发表时间：
2009-09-02
期刊：
影响因子：
3.8
通讯作者：
Marsolier-Kergoat, Marie-Claude
中科院分区：
文献类型：
--
作者：
Clemenson, Celine;Marsolier-Kergoat, Marie-Claude
DNA损伤检查点是检测核DNA病理结构并诱导适当反应的应激反应途径。这些反应包括细胞周期停滞、组蛋白修饰、转录程序的变化和参与DNA修复的蛋白质的翻译后修饰。DNA损伤检查点反应的失活可以在两种情况下发生：要么DNA损伤已经消失，整个途径在称为恢复的过程中失活，要么DNA损伤持续存在，但全部或部分途径仍然失活，这称为适应。我们在这里提出的审查这些失活过程的DNA损伤检查点主要是在芽殖酵母酿酒酵母，但也参考了粟酒裂殖酵母和动物细胞中的研究。(C)2009爱思唯尔有限公司版权所有。
The DNA damage checkpoint is a stress response pathway detecting pathological structures of nuclear DNA and inducing appropriate responses. These responses include cell cycle arrests, histone modifications, changes in the transcription programme and post-translational modifications of proteins involved in DNA repair. Inactivation of the DNA damage checkpoint responses can occur under two circumstances: either DNA damage has disappeared and the whole pathway is inactivated in a process termed recovery, or DNA damage persists but all or part of the pathway is nevertheless inactivated, which is called adaptation. We present here a review of these inactivating processes of the DNA damage checkpoint primarily in the budding yeast Saccharomyces cerevisiae but also with reference to studies in Schizosaccharomyces pombe and in animal cells. (C) 2009 Elsevier B.V. All rights reserved.