Multiparameter diffusion-weighted imaging for characterizing pathological patterns in lupus nephritis patients: A preliminary study
Multiparameter diffusion-weighted imaging for characterizing pathological patterns in lupus nephritis patients: A preliminary study
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多参数弥散加权成像表征狼疮性肾炎患者的病理模式：初步研究
DOI：
10.1002/jmri.26657
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发表时间：
2019-10-01
影响因子：
4.4
通讯作者：
Suo, Shiteng
中科院分区：
文献类型：
--
作者：
Zhang, Shan;Lin, Yanwei;Suo, Shiteng
研究背景狼疮性肾炎（LN）肾脏的炎症细胞浸润或纤维化等微结构改变可影响水分子的运动或扩散，因此扩散加权成像（DWI）有望成为评价LN肾脏病变的一种有价值的工具。目的探讨多参数弥散加权成像（mDWI）对LN的诊断价值。研究类型回顾性。22例LN患者。使用3.0 T扫描仪进行场强/序列多b值DWI。评估表观扩散系数（ADC）（m）、灌注相关扩散系数（D-f）、分子扩散系数（D-s）、灌注分数（f）、ADC（s）、α、ADC（k）和平均峰度（MK）分别通过单指数、双指数、拉伸指数和峰度模型拟合计算。统计检验独立样本t检验、Pearson分析和受试者操作特征（ROC）。结果在全组，活动指数（AI）与髓质α值呈显著正相关（rho =-0.54，P = 0.03）。慢性指数（CI）与髓质D-s值显著相关（rho =-0.61，P = 0.02）。其他扩散参数与组织学分级之间均无显著相关性，P > 0.05。对于区分增殖性LN（III或IV类）与V类，髓质中α的ROC曲线下面积（AUC）为0.833（P = 0.023）。结论mDWI可用于LN的病理类型的定性。技术有效性阶段：2 J. Magn. Reson。Imaging 2019;50：1075-1084.
Background Microstructural changes of lupus nephritis (LN) kidney such as inflammatory cell infiltration or fibrosis could influence water molecular movement or diffusion, which indicates that diffusion-weighted imaging (DWI) may become a valuable tool in evaluation of this disease. Purpose To explore whether multiparameter diffusion-weighted imaging (mDWI) could contribute to characterize pathological patterns in LN patients. Study Type Retrospective. Population Twenty-two patients with LN. Field Strength/Sequence Multi-b value DWI was performed with a 3.0 T scanner. Assessment Apparent diffusion coefficient (ADC)(m), perfusion-related diffusion coefficient (D-f), molecular diffusion coefficient (D-s), perfusion fraction (f), ADC(s), alpha, ADC(k), and mean kurtosis (MK) were calculated by monoexponential, biexponential, stretched-exponential, and kurtosis models fits, respectively. Statistical Tests Independent sample t-test, Pearson analysis and receiver operating characteristic (ROC). Results In the whole group, the activity index (AI) correlated significantly with alpha values in the medulla (rho = -0.54, P = 0.03). The chronicity index (CI) correlated significantly with D-s values in the medulla (rho = -0.61, P = 0.02). No significant association was found between any other diffusion parameter and histologic grade with all P > 0.05. For differentiating proliferative LN (Class III or IV) from Class V, the area under the ROC curve (AUC) of alpha in the medulla was 0.833 (P = 0.023). Data Conclusion mDWI might be used for the characterization of pathological patterns in LN patients. Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2019;50:1075-1084.