Randomised controlled trial of food elimination diet based on IgG antibodies for the prevention of migraine like headaches
Randomised controlled trial of food elimination diet based on IgG antibodies for the prevention of migraine like headaches
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DOI：
10.1186/1475-2891-10-85
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发表时间：
2011-08-11
影响因子：
5.4
通讯作者：
Torgerson, David J.
中科院分区：
文献类型：
--
作者：
Mitchell, Natasha;Hewitt, Catherine E.;Torgerson, David J.
背景：研究表明，食物不耐受可能是偏头痛等头痛的诱发因素。目的：评估 ELISA（酶联免疫吸附测定）测试的有效性以及随后的饮食消除建议，以预防偏头痛等头痛。设计：随机对照试验。背景：英国社区志愿者。参与者：符合偏头痛等头痛纳入标准并患有一种或多种食物不耐受的志愿者。在研究中。参与者收到真实饮食（n = 84）或假饮食（n = 83）表。建议参与者在 12 周内从饮食中去除不耐受食物。主要结果指标：12 周内头痛天数（MIDAS 调查问卷 A 项）。其他指标包括 MIDAS 总分和 HIT-6 总分。 结果：结果表明，12 周内偏头痛样头痛的数量略有减少，但这种差异并不具有统计学意义（IRR 1.15 95% CI 0.94 至 1.41，p = 0.18）。在第 4 周评估中，使用 ELISA 测试以及随后的饮食消除建议显着减少了偏头痛样头痛的数量（IRR 1.23 95% CI 1.01 至 1.50，p = 0.04）。真实饮食组和假饮食组之间偏头痛的失能和对日常生活的影响没有显着差异。结论：使用 ELISA 测试并随后采取饮食消除建议并没有减少 12 周时偏头痛样头痛的失能或对日常生活的影响或偏头痛样头痛的数量，但确实显着减少了 4 周时偏头痛样头痛的数量。
Background: Research suggests that food intolerance may be a precipitating factor for migraine like headaches.Aim: To evaluate the effectiveness of the ELISA (Enzyme Linked Immuno-Sorbent Assay) Test and subsequent dietary elimination advice for the prevention of migraine like headaches.Design: Randomised controlled trial.Setting: Community based volunteers in the UK.Participants: Volunteers who met the inclusion criteria for migraine like headaches and had one or more food intolerance were included in the study. Participants received either a true diet (n = 84) or a sham diet (n = 83) sheet. Participants were advised to remove the intolerant foods from their diet for 12 weeks.Main outcome measures: Number of headache days over a 12 week period (item A MIDAS questionnaire). Other measures includes the total MIDAS score and total HIT-6 score.Results: The results indicated a small decrease in the number of migraine like headaches over 12 weeks, although this difference was not statistically significant (IRR 1.15 95% CI 0.94 to 1.41, p = 0.18). At the 4 week assessment, use of the ELISA test with subsequent diet elimination advice significantly reduced the number of migraine like headaches (IRR 1.23 95% CI 1.01 to 1.50, p = 0.04). The disability and impact on daily life of migraines were not significantly different between the true and sham diet groups.Conclusions: Use of the ELISA test with subsequent diet elimination advice did not reduce the disability or impact on daily life of migraine like headaches or the number of migraine like headaches at 12 weeks but it did significantly reduce the number of migraine like headaches at 4 weeks.