A common precursor for glia and neurons in the embryonic CNS of Drosophila gives rise to segment-specific lineage variants.
A common precursor for glia and neurons in the embryonic CNS of Drosophila gives rise to segment-specific lineage variants.
复制标题
果蝇胚胎中枢神经系统中神经胶质细胞和神经元的共同前体产生了片段特异性谱系变异。
作者：
Gerald Udolph;Andreas Prokop;T. Bossing;G. Technau
神经系统由两类细胞组成，神经元和胶质细胞，它们在形态和功能上有所不同。它们来源于位于外胚层神经源性区域的前体。在这项研究中，我们展示了果蝇神经外胚层前体的完整胚胎谱系，该前体在腹部中枢神经系统中产生神经元和胶质细胞。这种谱系在不同种类的果蝇中是保守的。我们发现，在这个克隆中，神经元和胶质细胞类型来源于一个分离前体，以前被描述为NB1-1。因此，除了神经母细胞和成胶质细胞外，果蝇中还存在第三类中枢神经系统前体，我们称之为神经胶质母细胞。我们进一步表明NB -1谱系在细胞水平上表现出特征性的片段特异性差异。
The nervous system consists of two classes of cells, neurons and glia, which differ in morphology and function. They derive from precursors located in the neurogenic region of the ectoderm. In this study, we present the complete embryonic lineage of a neuroectodermal precursor in Drosophila that gives rise to neurons as well as glia in the abdominal CNS. This lineage is conserved among different Drosophila species. We show that neuronal and glial cell types in this clone derive from one segregating precursor, previously described as NB1-1. Thus, in addition to neuroblasts and glioblasts, there exists a third class of CNS precursors in Drosophila, which we call neuroglioblasts. We further show that the NB 1-1 lineage exhibits characteristic segment-specific differences on the cellular level.
有丝分裂域揭示了果蝇胚胎中细胞的早期定型。
DOI：
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发表时间：
1989
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Foe,VE
通讯作者：
Foe,VE
果蝇胚胎发生过程中的程序性细胞死亡。
DOI：
10.1242/dev.117.1.29
发表时间：
1993
期刊：
Development (Cambridge, England)
影响因子：
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作者：
Abrams,JM;White,K;Fessler,LI;Steller,H
通讯作者：
Steller,H