Versican: signaling to transcriptional control pathways
Versican: signaling to transcriptional control pathways
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DOI：
10.1139/y05-154
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发表时间：
2006-01-01
影响因子：
2.1
通讯作者：
McManus, BM
中科院分区：
文献类型：
--
作者：
Rahmani, M;Wong, BW;McManus, BM
Versican是一种硫酸软骨素蛋白聚糖，是细胞外基质的主要成分之一，在发育和疾病的关键事件期间提供松散和水合的基质。Versican参与细胞粘附、增殖、迁移和血管生成，因此在组织形态发生和维持中起核心作用。此外，多功能蛋白聚糖有助于许多病理过程的发展，包括动脉粥样硬化性血管疾病、癌症、肌腱重塑、毛囊循环、中枢神经系统损伤和神经突生长。Versican是一种由模块化核心蛋白结构域和糖胺聚糖侧链组成的复杂分子，并且存在多种合成步骤和调节过程。此外，多功能蛋白聚糖在多种细胞类型和不同的发育和病理时间框架中存在不同的时间和空间表达。为了充分理解多功能蛋白聚糖的功能作用，因为它涉及到在发展和疾病的表达模式的变化，深入了解多功能蛋白聚糖的生物合成过程是必要的。这篇综述的目的是评估目前的状态，我们的知识关于多功能蛋白聚糖基因调控的转录控制。我们将集中在信号转导途径，启动子区域，顺式作用元件，和反式因子，已被表征。
Versican, a chondroitin sulfate proteoglycan, is one of the main components of the extracellular matrix, which provides a loose and hydrated matrix during key events in development and disease. Versican participates in cell adhesion, proliferation, migration, and angiogenesis, and hence plays a central role in tissue morphogenesis and maintenance. In addition, versican contributes to the development of a number of pathologic processes including atherosclerotic vascular diseases, cancer, tendon remodeling, hair follicle cycling, central nervous system injury, and neurite outgrowth. Versican is a complex molecule consisting of modular core protein domains and glycosaminoglycan side chains, and there are various steps of synthesis and processes regulating them. Also, there is differential temporal and spatial expression of versican by multiple cell types and in different developmental and pathological time frames. To fully appreciate the functional roles of versican as it relates to changing patterns of expression in development and disease, an in depth knowledge of versican's biosynthetic processing is necessary. The goal of this review is to evaluate the current Status Of Our knowledge regarding the transcriptional control of versican gene regulation. We will be focusing on the signal transduction pathways, promoter regions, cis-acting elements, and trans-factors that have been characterized.