Mechanism of CD1d-restricted natural killer T cell activation during microbial infection
Mechanism of CD1d-restricted natural killer T cell activation during microbial infection
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DOI：
10.1038/ni1002
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发表时间：
2003-12-01
影响因子：
30.5
通讯作者：
Brenner, MB
中科院分区：
文献类型：
--
作者：
Brigl, M;Bry, L;Brenner, MB
cd1 -限制性自然杀伤T （NKT）细胞对宿主防御多种微生物病原体非常重要。在感染过程中，这些T细胞如何以及何时被生理激活尚不清楚。我们的数据支持一个模型，其中NKT细胞使用一种独特的激活机制，不需要它们识别微生物抗原。相反，树突状细胞对微生物产物产生的白细胞介素12扩增了对cd1呈递的自身抗原的弱反应，从而产生了强效的干扰素分泌。NKT细胞是鼠伤寒沙门菌感染时最先反应的淋巴细胞之一，它们在体内的激活也依赖于白细胞介素12和CD1d识别。我们认为这种激活机制是NKT细胞在不同微生物感染中快速激活的主要途径。
CD1d-restricted natural killer T (NKT) cells are important for host defense against a variety of microbial pathogens. How and when these T cells become activated physiologically during infection remains unknown. Our data support a model in which NKT cells use a unique activation mechanism not requiring their recognition of microbial antigens. Instead, weak responses to CD1d-presented self antigens were amplified by interleukin 12 made by dendritic cells in response to microbial products, resulting in potent interferon-gamma secretion. NKT cells were among the first lymphocytes to respond during Salmonella typhimurium infection, and their activation in vivo also depended on interleukin 12 and CD1d recognition. We propose this mechanism of activation as a major pathway responsible for the rapid activation of NKT cells in different microbial infections.