Differential regulation of the antibody responses to Gag and Env proteins of human immunodeficiency virus type 1
Differential regulation of the antibody responses to Gag and Env proteins of human immunodeficiency virus type 1
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DOI：
10.1128/jvi.71.4.2799-2809.1997
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发表时间：
1997-04-01
影响因子：
5.4
通讯作者：
Moore, JP
中科院分区：
文献类型：
--
作者：
Binley, JM;Klasse, PJ;Moore, JP
我们研究了人类免疫缺陷病毒1型(HIV-1)的Env和Gag抗原在几组HIV-1感染者中的抗体反应：长期无进展者、疾病进展者、急性血清转换者和HIV-1蛋白酶抑制剂的接受者。我们的结论是，对Env和Gag抗原的抗体反应是不同的调节，血浆病毒载量在可测量的范围内(每毫升500至10(8)个RNA拷贝)的变化不直接影响对这些HIV-1蛋白的抗体反应。我们提供了对血浆中HIV-1特异性免疫球蛋白G浓度的定量估计，一旦对HIV-1的免疫反应在血清转换后稳定下来，抗gp120和抗p24抗体的浓度可能超过1 mg/ml。我们讨论了明显的游行，即抗GAG抗体的缺乏(充其量，抗病毒活性有限)是疾病进展的指示，而抗Env抗体的保留(确实具有抗病毒活性)的预后价值有限(或没有)。我们表明，在疾病进展过程中，抗Gag抗体的消失极不可能是由于免疫络合；相反，我们认为它反映了T细胞帮助的丧失，而T细胞帮助对于抗Gag比抗Env反应更有必要。
We have studied the antibody responses to Env and Gag antigens of human immunodeficiency virus type 1 (HIV-1) in several cohorts of HIV-1 infected individuals: long-term nonprogressors, progressors to disease, acute seroconvertors, and recipients of HIV-1 protease inhibitors. We conclude that the antibody responses to Env and Gag antigens are differentially regulated and that changes in the plasma viral load in the measurable range (500 to 10(8) RNA copies per ml) do not directly affect the antibody responses to these HIV-1 proteins. We provide quantitative estimates of HIV-1-specific immunoglobulin G concentrations in plasma, which can be in excess of 1 mg/ml for both anti-gp120 and anti-p24 once the immune response to HIV-1 has stabilized after seroconversion. We discuss the apparent parades that the absence of anti-Gag antibodies (which have, at best, limited antiviral activity) is indicative of disease progression, while the retention of anti-Env antibodies (which do have antiviral activity) is of limited (or no) prognostic value. We show that the disappearance of anti-Gag antibodies during disease progression is highly unlikely to be due to immune complexing; instead, we believe that it reflects the loss of T-cell help that is more necessary for the anti-Gag than the anti-Env response.