Mathematical modelling of cancer invasion: Implications of cell adhesion variability for tumour infiltrative growth patterns
Mathematical modelling of cancer invasion: Implications of cell adhesion variability for tumour infiltrative growth patterns
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DOI：
10.1016/j.jtbi.2014.07.010
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发表时间：
2014-11-21
影响因子：
2
通讯作者：
Chaplain, Mark A. J.
中科院分区：
文献类型：
--
作者：
Domschke, Pia;Trucu, Dumitru;Chaplain, Mark A. J.
肿瘤侵袭是一个复杂的多尺度现象，涉及不同时空尺度上许多相互关联的遗传、生化、细胞和组织过程，是癌症的标志之一。侵袭的核心是癌细胞改变和降解细胞外基质的能力。再加上细胞-细胞和细胞-基质黏附改变而激活和增强的异常过度增殖和迁移，癌性肿块可侵入邻近组织。随着肿瘤诱导的血管生成，侵袭是转移扩散的关键组成部分，最终导致在宿主身体其他部位形成继发性肿瘤。在本文中，我们探讨了癌症侵袭模型的时空动力学，其中细胞-细胞和细胞-基质粘附通过偏积分-微分方程系统中的非局部相互作用项来解释。通过细胞群内以及细胞与细胞外基质组分之间的粘附特性的时间依赖性，研究了癌症生长和发育过程中粘附特性的变化。我们的计算模拟结果证明了一系列异质性动力学，这些动力学在质量上类似于在许多不同类型的癌症中观察到的侵袭性生长模式，例如肿瘤浸润性生长模式（INF）。(C) 2014 Elsevier Ltd.版权所有。
Cancer invasion, recognised as one of the hallmarks of cancer, is a complex, multiscale phenomenon involving many inter-related genetic, biochemical, cellular and tissue processes at different spatial and temporal scales. Central to invasion is the ability of cancer cells to alter and degrade an extracellular matrix. Combined with abnormal excessive proliferation and migration which is enabled and enhanced by altered cell-cell and cell-matrix adhesion, the cancerous mass can invade the neighbouring tissue. Along with tumour-induced angiogenesis, invasion is a key component of metastatic spread, ultimately leading to the formation of secondary tumours in other parts of the host body.In this paper we explore the spatio-temporal dynamics of a model of cancer invasion, where cell-cell and cell-matrix adhesion is accounted for through non-local interaction terms in a system of partial integro-differential equations. The change of adhesion properties during cancer growth and development is investigated here through time-dependent adhesion characteristics within the cell population as well as those between the cells and the components of the extracellular matrix. Our computational simulation results demonstrate a range of heterogeneous dynamics which are qualitatively similar to the invasive growth patterns observed in a number of different types of cancer, such as tumour infiltrative growth patterns (INF). (C) 2014 Elsevier Ltd. All rights reserved.