Integration of what and where in the primate prefrontal cortex
Integration of what and where in the primate prefrontal cortex
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DOI：
10.1126/science.276.5313.821
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发表时间：
1997-05-02
期刊：
影响因子：
56.9
通讯作者：
Miller, EK
中科院分区：
文献类型：
--
作者：
Rao, SC;Rainer, G;Miller, EK
视觉系统将对象的形状和颜色的处理与其空间位置(位置)分离。为了将动作定向到对象，这些对象的身份和位置必须以某种方式结合在一起。为了检验这一过程是否发生在前额叶(PF)皮质内，研究人员记录了195个前额叶(PF)神经元的活动，这项任务涉及什么和哪里的工作记忆。一些神经元表现出物体调节(What)或位置调节(Where)的延迟活动。然而，超过一半(52%，或/123)的延迟活动的PF神经元既显示了什么调谐，也显示了哪里调谐。这些神经元可能有助于将物体信息与指导行为所需的空间信息联系起来。
The visual system separates processing of an object's form and color (''what'') from its spatial location (''where''). In order to direct action to objects, the identity and location of those objects must somehow be integrated. To examine whether this process occurs within the prefrontal (PF) cortex, the activity of 195 PF neurons was recorded during a task that engaged both what and where working memory. Some neurons showed either object-tuned (what) or location-tuned (where) delay activity. However, over half (52 percent, or 64/123) of the PF neurons with delay activity showed both what and where tuning. These neurons may contribute to the linking of object information with the spatial information needed to guide behavior.