Protein and Imaging Biomarkers in the Eye for Early Detection of Alzheimer's Disease.
Protein and Imaging Biomarkers in the Eye for Early Detection of Alzheimer's Disease.
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DOI：
10.3233/adr-210283
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发表时间：
2021-05-03
期刊：
影响因子：
--
通讯作者：
Subramanian ML
中科院分区：
文献类型：
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作者：
Fereshetian S;Agranat JS;Siegel N;Ness S;Stein TD;Subramanian ML
阿尔茨海默病(AD)是世界范围内导致痴呆的最常见原因之一。虽然目前尚无正规的治疗阿尔茨海默病的方法，但已进行了大量研究，以确定早期发现这种疾病的生物标志物，从而改善后续的治疗。鉴于眼睛可以相对容易地进行非侵入性检查和成像，它已经成为一个令人兴奋的研究领域，以寻找生物标记物的证据，并有助于AD的早期诊断。这篇综述探讨了眼部蛋白质和视网膜成像生物标记物的研究现状。在此，对文献中有关与晶状体、视网膜和其他眼结构相关的AD生物标志物的主要发现进行了综述。
Alzheimer’s disease (AD) is one of the most common causes of dementia worldwide. Although no formal curative therapy exists for the treatment of AD, considerable research has been performed to identify biomarkers for early detection of this disease, and thus improved subsequent management. Given that the eye can be examined and imaged non-invasively with relative ease, it has emerged as an exciting area of research for evidence of biomarkers and to aid in the early diagnosis of AD. This review explores the current understanding of both protein and retinal imaging biomarkers in the eye. Herein, primary findings in the literature regarding AD biomarkers associated with the lens, retina, and other ocular structures are reviewed.