Bovine carboxylesterases: Evidence for two CES1 and five families of CES genes on chromosome 18
Bovine carboxylesterases: Evidence for two CES1 and five families of CES genes on chromosome 18
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DOI：
10.1016/j.cbd.2008.09.002
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发表时间：
2009-03-01
影响因子：
3
通讯作者：
VandeBerg, John L.
中科院分区：
文献类型：
--
作者：
Holmes, Roger S.;Cox, Laura A.;VandeBerg, John L.
预测牛羧酸酯酶（CES）蛋白质和基因序列来自牛（普通牛）基因组序列数据。两个牛CES 1基因（CES1.1和CES1.2）位于18号染色体上，编码的氨基酸序列有81%相同。还观察到两种形式的CES1.2，显然是由C-末端编码的indel多态性引起的。在18号染色体上观察到两个CES基因簇：CES 5-CES 1.1-CES 1.2和CES 2-CES 3-CES 6。牛CES 1、CES 2、CES 3、CES和CES 6彼此共享39-45%的同一性，但与五个相应的人CES家族成员中的每一个显示71-76%的同一性。系统发育研究表明，牛CES基因起源于五个祖先的基因复制事件，早于真兽目哺乳动物的共同祖先。此外，随后的CES 1基因复制事件提出在哺乳动物进化过程中之前的牛科共同祖先的外观类似于20 MY前。(C)2008年爱思唯尔公司All rights reserved.
Predicted bovine carboxylesterase (CES) protein and gene sequences were derived from bovine (Bos taurus) genomic sequence data. Two bovine CES1 genes (CES1.1 and CES1.2) were located on chromosome 18 encoding amino acid sequences that were 81% identical. Two forms of CES1.2 were also observed apparently caused by an indel polymorphism encoded at the C-terminus end. Two CES gene clusters were observed on chromosome 18: CES5-CES1.1-CES1.2 and CES2-CES3-CES6. Bovine CES1, CES2, CES3, CESS and CES6 shared 39-45% identity with each other, but showed 71-76% identity with each of the five corresponding human CES family members. Phylogeny studies indicated that bovine CES genes originated from five ancestral gene duplication events which predated the eutherian mammalian common ancestor. In addition, a subsequent CES1 gene duplication event is proposed during mammalian evolution prior to the appearance of the Bovidae common ancestor similar to 20 MY ago. (C) 2008 Elsevier Inc. All rights reserved.