PML-RARα‐positive cells contribute to scrotal ulceration with all‐trans retinoic acid
PML-RARα‐positive cells contribute to scrotal ulceration with all‐trans retinoic acid
复制标题
PML-RARα阳性细胞与全反式视黄酸导致阴囊溃疡
DOI：
10.1111/ijd.15664
复制
发表时间：
2021
影响因子：
3.6
通讯作者：
Kadowaki Norimitsu
中科院分区：
文献类型：
--
作者：
Imataki Osamu;Yoshida Shunsuke;Kaji Tomohiro;Kida Jun‐ichiro;Kubo Hiroyuki;Uemura Makiko;Fujita Haruyuki;Kadowaki Norimitsu
此外，APL细胞浸润必须诊断，因为APL细胞在发病时的皮肤受累是与患者生存率降低相关的主要风险因素。对于急性早幼粒细胞白血病（APL），全反式维甲酸（ATRA）诱导治疗可能有效; 1然而，ATRA诱导中性粒细胞分化，可能与副作用有关。2最突出的副作用是辨证分型。2第二大ATRA相关副作用是Sweet综合征，也被称为嗜中性皮肤病，其特征是发生嗜中性浸润性红斑和发热。3这些ATRA相关综合征的诊断和鉴别可能很困难。PML-RAR阳性细胞与全反式视黄酸一起促成阴囊溃疡。国际皮肤病学杂志的版权是Wiley-Blackwell的财产，未经版权保持器的明确书面许可，其内容不得复制或通过电子邮件发送到多个网站或发布到列表服务器。但是，用户可以打印，下载或电子邮件的文章供个人使用。这篇摘要可以删节。不保证副本的准确性。用户应参考原始出版版本的材料的完整摘要。版权适用于所有摘要。
Additionally, APL cell infiltration must be diagnosed because the cutaneous involvement of APL cells at onset is a major risk factor associated with reduced patient survival. Dear Editor, For acute promyelocytic leukemia (APL), induction therapy with all-trans retinoic acid (ATRA) can be effective; 1 however, ATRA induces neutrophil differentiation and may be associated with side effects. 2 The most prominent associated side effect is differentiation syndrome. 2 The second-leading ATRA-associated side effect is Sweet syndrome, also referred to as neutrophilic dermatosis, which is characterized by the development of neutrophil-infiltrating erythema and fever. 3 The diagnosis and discrimination between these ATRA-associated syndromes can be difficult. PML-RAR-positive cells contribute to scrotal ulceration with all-trans retinoic acid.[Extracted from the article]Copyright of International Journal of Dermatology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. Copyright applies to all Abstracts.