REDUCTION OF FOOD-INTAKE AND BODY-WEIGHT BY CHRONIC INTRAVENTRICULAR INSULIN INFUSION
REDUCTION OF FOOD-INTAKE AND BODY-WEIGHT BY CHRONIC INTRAVENTRICULAR INSULIN INFUSION
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DOI：
10.1016/0361-9230(84)90174-6
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发表时间：
1984-01-01
影响因子：
3.8
通讯作者：
DAVIS, JD
中科院分区：
文献类型：
--
作者：
BRIEF, DJ;DAVIS, JD
本实验观察了3种剂量(5、7.5、10mU/d)中的1种胰岛素慢性注入大鼠第三脑室对大鼠摄食量、饮水量和体质量的影响。溶液以1微升/小时的速率通过渗透微泵输注7天。2个最高剂量的胰岛素对进食量和体重减轻的抑制作用与剂量相关，大于每天5亩或对照输注林格氏溶液的效果。5亩/天对小鼠摄食量、饮水量和体重的影响与对照组相似。所有接受胰岛素治疗的组都减少了白天和晚上的食物摄入量，尽管只有夜间食物摄入量的差异有统计学意义。10亩/天也比其他任何一种解决方案都显著减少了水的摄入量。注射胰岛素的动物体重减轻不能仅用卡路里摄入量的减少来解释。所有组的食物摄入量在输液后7天结束时恢复正常，在接受最高剂量胰岛素的动物中恢复最慢。所有动物恢复体重的速度大致相同。脑胰岛素在调节食物摄入量和体重方面起着重要作用。
The effect of chronic infusions of insulin in 1 of 3 doses (5, 7.5 or 10 mU/day) into the 3rd ventricle, on food and water intake and body wt was examined in the rat. Solutions were infused via osmotic minipumps at a rate of 1 .mu.l/h for 7 days. The 2 highest doses of insulin produced a dose-related suppression of food intake and weight loss, which was greater than the effect produced by 5 mU/day or a control infusion of Ringers solution. The effect of 5 mU/day on food and water intake and body weight was similar to the effect of the control infusion. All groups treated with insulin decreased food intake during the day and night, although only differences in nighttime food intake were statistically significant. Ten mU/day also produced a significantly greater reduction in water intake than each of the other solutions. Weight loss in the animals infused with insulin could not be explained by a decrease in caloric intake alone. Food intake returned to normal in all groups by the end of a 7 day post-infusion period, with recovery being slowest among the animals receiving the highest doses of insulin. All animals recovered body weight at approximately the same rate. Brain insulin plays a role in the regulation of food intake and body wt.