Periodontal disease and rheumatoid arthritis: the evidence accumulates for complex pathobiologic interactions.
Periodontal disease and rheumatoid arthritis: the evidence accumulates for complex pathobiologic interactions.
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DOI：
10.1097/bor.0b013e32835fb8ec
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发表时间：
2013-05
影响因子：
5.1
通讯作者：
Moni M
中科院分区：
文献类型：
--
作者：
Bingham CO 3rd;Moni M
本综述的重点是最近与牙周病和类风湿性关节炎之间的关联相关的临床和转化研究。人们对口腔健康与自身免疫性疾病和炎症性疾病之间的关联越来越感兴趣。许多流行病学研究描述了类风湿性关节炎和牙周病之间的关联。最近的临床研究继续支持这些报告，并且越来越多地与生物学评估联系起来，以更好地了解这些关系的本质。最近的许多研究评估了牙龈卟啉单胞菌、口腔微生物组以及位点特异性和底物特异性瓜氨酸化的机制。这些有助于进一步阐明这两种炎症性疾病过程之间的相互作用。对临床口腔健康参数、牙龈微环境、自身抗体和生物标志物以及类风湿性关节炎疾病活动测量的研究有助于更好地了解类风湿性关节炎和牙周病关联的潜在机制。累积的结果和正在进行的研究有望确定新的机制和干预策略，以改善这两种情况的患者预后。
This review was conducted to focus on the recent clinical and translational research related to the associations between periodontal disease and rheumatoid arthritis. There is a growing interest in the associations between oral health and autoimmune and inflammatory diseases. A number of epidemiologic studies have described associations between rheumatoid arthritis and periodontal disease. Recent clinical studies continue to support these reports, and are increasingly linked with biological assessments to better understand the nature of these relationships. A number of recent studies have evaluated the periopathogenic roles of Porphyromonas gingivalis, the oral microbiome, and mechanisms of site-specific and substrate-specific citrullination. These are helping to further elucidate the interactions between these two inflammatory disease processes. Studies of clinical oral health parameters, the gingival microenvironment, autoantibodies and biomarkers, and rheumatoid arthritis disease activity measures are providing a better understanding of the potential mechanisms responsible for rheumatoid arthritis and periodontal disease associations. The cumulative results and ongoing studies have the promise to identify novel mechanisms and interventional strategies to improve patient outcomes for both conditions.