Entamoeba histolytica causes intestinal secretion: role of serotonin.
Entamoeba histolytica causes intestinal secretion: role of serotonin.
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溶组织内阿米巴引起肠道分泌：血清素的作用。
DOI：
10.1126/science.6308760
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Donowitz,M
中科院分区：
文献类型：
--
作者：
McGowan,K;Kane,A;Asarkof,N;Wicks,J;Guerina,V;Kellum,J;Baron,S;Gintzler,AR;Donowitz,M
溶组织内阿米巴原虫的裂解物在兔回肠和大鼠结肠浆膜表面时改变了主动电解质转运。裂解物诱导的对电解质转运的作用与5-羟色胺引起的作用相似，并被蟾毒肽（一种已知抑制5-羟色胺作用的类似物）阻断。5-羟色胺抗体可部分抑制这种转运作用。通过放射免疫测定、高效液相色谱法和薄层色谱法证实阿米巴裂解物中含有5-羟色胺。这些结果提示溶组织内阿米巴的5-羟色胺可能在阿米巴病的腹泻中起重要作用。
Lysates of the protozoan parasiteEntamoeba histolyticaaltered active electrolyte transport when present on the serosal surface of rabbit ileum and rat colon. The lysate-induced effects on electrolyte transport were similar to those caused by serotonin, and were blocked by bufotenine, an analog known to inhibit the action of serotonin. The transport effects were partially inhibited by antibody to serotonin. The amebic lysates were shown to contain serotonin by radioimmunoassay, high-performance liquid chromatography, and thin-layer chromatography. These results suggest that the serotonin present inEntamoeba histolyticamay be important in the diarrhea seen in amebiasis.