Highly fluorinated metal complexes as dual 19F and PARACEST imaging agents.
Highly fluorinated metal complexes as dual 19F and PARACEST imaging agents.
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作为双 19F 和 PARACEST 显像剂的高度氟化金属络合物。
DOI：
10.1039/c9dt01852b
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Que,EmilyL
中科院分区：
文献类型：
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作者：
Yu,Meng;Bouley,BaileyS;Xie,Da;Que,EmilyL
我们报道了一组水溶性过渡金属配合物，可用作 19F 和 PARACEST 磁共振成像剂。正如体外 19 F MRI 实验所证明的，大量等效氟原子和金属的顺磁效应为这些配合物提供了高 19 F 灵敏度。该复合物含有附加到循环大环上的甲酰胺基团，可提供与本体水良好区分的 1H CEST 峰。 Co(II) 试剂显示两个 CEST 峰，可用于比率 pH 测定，并且使用 Fe(II) 络合物证明了将 19F MR 和 PARACEST 结合作为补充成像技术的概念。
We reported a set of water-soluble transition metal complexes that can serve as both 19F and PARACEST magnetic resonance imaging agents. The high number of equivalent fluorine atoms and the paramagnetic effect of metals offer these complexes high 19F sensitivity as demonstrated by in vitro19F MRI experiments. The complexes contain carboxamide groups appended onto a cyclen macrocycle, which provide 1H CEST peaks well differentiated from bulk water. The Co(II) agent displays two CEST peaks that can be utilized for ratiometric pH determination and the concept of combining 19F MR and PARACEST as complementary imaging techniques was demonstrated with the Fe(II) complex.