The effect of Job's tears-enriched yoghurt on GLP-1, calprotectin, blood glucose levels and weight of patients with type 2 diabetes mellitus
The effect of Job's tears-enriched yoghurt on GLP-1, calprotectin, blood glucose levels and weight of patients with type 2 diabetes mellitus
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DOI：
10.3233/mnm-180258
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发表时间：
2019-01-01
影响因子：
1.1
通讯作者：
Ali, Soegianto
中科院分区：
文献类型：
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作者：
Djaja, Nanny;Permadi, Inge;Ali, Soegianto
背景：天然食品成分在糖尿病患者血糖控制中的作用已被广泛研究。然而，关于其成分对改善临床、实验室和肠道功能指标的作用的信息很少。目的：本研究旨在检测富含薏米的酸奶对2型糖尿病患者体重、空腹血糖、GLP-1和钙卫蛋白的影响。对照组（C组）和实验组（T组）分别饮用酸奶和富含薏米的酸奶。仅允许受试者使用二甲双胍。薏米种子是用标准方法提取的。测量身高和体重。使用标准方法进行空腹血糖、GLP-1和钙卫蛋白的实验室检查。应用适当的统计分析检验来检查组内和组间的变量变化。显著性设为p <0.05。两组体重和FBG均显著降低（C组体重：64.5 vs 63.5 kg，p = 0.01; C组FBG：130.7 vs 128.7 mg/dL，p = 0.04; T组体重：64.8 vs 63.1 kg，p = 0.01; T组FBG：129.2 vs 110.8 mg/dL，p = 0.03），T组降低更大（体重; -1.01 vs -1.68 kg，p = 0.02，FBG; -1.30 vs -18.1 mg/dL，p < 0.01）。钙卫蛋白在T组显著降低（36.1 vs 23.4 μ g/g，p = 0.02），但Delta变化与C组无显著差异。结论：添加薏米可增强酸奶对T2 DM患者的减肥和FBG的效果。
BACKGROUND: Involving natural food ingredients in controlling blood glucose in diabetic patients has been widely studied. However, there is little information about the effect of the ingredients on improvement of clinical, laboratory, and gut function markers.OBJECTIVE: This study was aimed to examine the effect of Job's tears-enriched yoghurt on weight, fasting blood glucose, GLP-1, and Calprotectin in patients with type 2 Diabetes Mellitus.METHODS: Sixty male and female subjects with T2DM participating in this study were divided in two groups; received yoghurt (control group/C) and Job's tears-enriched yoghurt (treatment group/T). Subjects use metformin only were allowed. Job's tears seed was extracted using a standard process. Height and weight were measured. Laboratory examination for fasting blood glucose, GLP-1, and calprotectin were performed using standard methods. Appropiate statistical analysis tests were applied to examine variables change within and between groups. Significancy was set at p < 0.05.RESULTS: Characteristics between groups were comparable. Weight and FBG reduced significantly in bothgroups (weight in C; 64.5 vs 63.5 kg, p = 0.01; FBG in C; 130.7 vs 128.7 mg/dL, p = 0.04, weight in T, 64.8 vs 63.1 kg, p = 0.01, FBG in T; 129.2 vs 110.8 mg/dL, p = 0.03) with greater reduced in T group (weight; -1.01 vs -1.68 kg, p = 0.02, FBG; -1.30 vs -18.1 mg/dL, p < 0.01). Calprotectin decreased significantly in T group (36.1 vs 23.4 mu g/g, p = 0.02) but Delta change was not significant different with C group.CONCLUSION: Adding Job's tear could enhance the effect of yoghurt in reducing weight and FBG in T2DM patients.