"Paradoxical kinesis" is not a hallmark of Parkinson's disease but a general property of the motor system
"Paradoxical kinesis" is not a hallmark of Parkinson's disease but a general property of the motor system
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DOI：
10.1002/mds.20987
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发表时间：
2006-09-01
影响因子：
8.6
通讯作者：
Desmurget, Michel
中科院分区：
文献类型：
--
作者：
Ballanger, Benedicte;Thobois, Stephane;Desmurget, Michel
虽然运动缓慢是帕金森病(PD)的典型特征，但有研究表明，严重残疾的患者在紧急或外部驱动的情况下仍能产生正常的运动反应。为了研究这种现象(通常被称为“矛盾运动”)，我们要求PD患者和健康受试者在三种主要条件下按下大开关：自我生成，产生尽可能快的运动；外部线索，与自身生成的相同，但对声音提示做出反应；紧急外部线索，与外部线索相同，具有控制电磁铁的开关，以防止球在倾斜的坡道底部失败。对两个实验组的任务难度进行均衡化。结果表明，外部线索和紧急条件会缩短运动持续时间(紧急外部线索和自身产生的外部线索)和反应时(紧急外部线索和外部线索)。帕金森病患者和健康受试者的减少量是相同的。这些观察表明，矛盾运动不是帕金森病的标志或基底节功能障碍的副产品，而是运动系统的一般特性。(C)2006年运动无序协会。
Although slowness of movement is a typical feature of Parkinson's disease (PD), it has been suggested that severely disabled patients remained able to produce normal motor responses in the context of urgent or externally driven situations. To investigate this phenomenon (often designated "paradoxical kinesis"), we required PD patients and healthy subjects to press a large switch under three main conditions: Self Generated, produce the fastest possible movement; External Cue, same as Self Generated but in response to an acoustic cue; Urgent External Cue, same as External Cue with the switch controlling an electromagnet that prevented a ball failing at the bottom of a tilted ramp. Task difficulty was equalized for the two experimental groups. Results showed that external cues and urgent conditions decreased movement duration (Urgent External Cue < External Cue < Self Generated) and reaction time (Urgent External Cue < External Cue). The amount of reduction was identical in PD patients and healthy subjects. These observations show that paradoxical kineses are not a hallmark of PD or a byproduct of basal ganglia dysfunctions, but a general property of the motor system. (c) 2006 Movement Disorder Society.