Low-dose homoharringtonine and cytarabine in combination with granulocyte colony-stimulating factor for elderly patients with de novo acute myeloid leukemia
Low-dose homoharringtonine and cytarabine in combination with granulocyte colony-stimulating factor for elderly patients with de novo acute myeloid leukemia
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DOI：
10.3109/10428194.2014.910774
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发表时间：
2015-01-01
影响因子：
2.6
通讯作者：
Yang, Jing
中科院分区：
文献类型：
--
作者：
Chen, Chen;Xu, Wei;Yang, Jing
在过去的几十年里，年轻急性髓系白血病(AML)的治疗有了很大的进步。然而，老年急性髓细胞白血病患者的管理仍然是一个挑战。采用高三尖杉酯碱联合阿糖胞苷联合粒细胞集落刺激因子(HCG)治疗56例老年初治AML患者。总有效率为75%，其中完全缓解60.7%，部分缓解14.3%。56例患者中有14例(25%)无反应。老年患者的CR率较高
The treatment of young patient with acute myeloid leukemia (AML) has improved dramatically during the past several decades. However, management of elderly patients with AML still remains a challenge. A total of 56 elderly patients with de novo AML were treated with homoharringtonine and cytarabine in combination with granulocyte colony-stimulating factor (HCG). The overall response rate was 75% (60.7%% complete response [CR] and 14.3% partial response). Fourteen (25%) of the 56 patients showed no response. A higher CR rate was observed in patients aged