Is there any correlation between amh and obesity in premenopausal women?
Is there any correlation between amh and obesity in premenopausal women?
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DOI：
10.1007/s00404-012-2363-x
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发表时间：
2012-09-01
影响因子：
2.6
通讯作者：
Seyisoglu, Hakan
中科院分区：
文献类型：
--
作者：
Sahmay, Sezai;Usta, Taner;Seyisoglu, Hakan
为探讨肥胖与非肥胖绝经前妇女血清抗苗勒管激素水平与体重指数的相关性，本横断面研究检测了因不孕症在我院生殖内分泌门诊就诊的45岁以下妇女血清抗苗勒管激素水平。222例患者的体重指数低于30 kg/m2，37例患者的体重指数等于或高于30 kg/m2。分析各组的抗副中肾管激素水平。从研究对象的血液样本中检测抗苗勒管激素、促卵泡激素、促黄体激素、雌二醇、催乳素和促甲状腺激素的水平，两组的平均年龄没有显著差异。两组间FSH、LH、雌二醇和催乳素水平无统计学显著差异。非肥胖和肥胖参与者的抗苗勒管激素水平分别为3.46 +/- A 2.79 ng/ml和3.79 +/- A 2.93 ng/ml。两组血清抗苗勒管激素（AMH）水平与BMI水平无显著相关性（P > 0.05），育龄妇女血清AMH水平与BMI无显著相关性（P > 0.05）。肥胖与血清促卵泡激素、促黄体激素、雌二醇、催乳素和促甲状腺激素水平无关。肥胖不太可能影响绝经前年龄组的卵巢储备。
To evaluate the correlation between the levels of anti-mullerian hormone and body mass index between obese and non-obese premenopausal women.Serum anti-mullerian hormone levels of women younger than 45 years admitted to our reproductive endocrinology clinic for investigation of infertility were examined in this cross-sectional study. Body mass indices were lower than 30 kg/m(2) in 222 patients and equal to or higher than 30 kg/m(2) in 37 patients. Levels of antimullerian hormone were analyzed in each group. Blood samples obtained from study subjects were assayed for levels of anti-mullerian hormone, follicle-stimulating hormone, luteinizing hormone, estradiol, prolactin and thyroid stimulating hormone.There was no significant difference in terms of mean age between the two groups. There was no statistically significant difference between these two groups in terms of FSH, LH, estradiol and prolactin levels. Anti-mullerian hormone levels were 3.46 +/- A 2.79 ng/ml and 3.79 +/- A 2.93 ng/ml in non-obese and obese participants, respectively. No statistically significant correlation was found between Anti Mullerian Hormone (AMH) levels and BMI levels in either group (P > 0.05).Body mass index does not have an effect on serum AMH levels in women of reproductive age. Obesity has no association with levels of serum follicle stimulating hormone, luteinizing hormone, estradiol, prolactin and thyroid stimulating hormone. Obesity is unlikely to affect ovarian reserve in the premenopausal age group.