Maternal amino acid supplementation for intrauterine growth restriction.
Maternal amino acid supplementation for intrauterine growth restriction.
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DOI：
10.2741/s162
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Rozance PJ
中科院分区：
文献类型：
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作者：
Brown LD;Green AS;Limesand SW;Rozance PJ
母体膳食蛋白补充剂，以改善胎儿生长已被认为是一种选择，以预防或治疗宫内生长受限。然而，与均衡膳食补充剂相反，已观察到接受大量膳食蛋白质补充剂的孕妇的不良围产期结果。这些不良结局的机制尚不清楚。本综述将讨论相关的人类和动物数据，为解释性假设的发展提供必要的背景，并最终为妊娠期治疗干预措施的发展提供必要的背景，以改善胎儿生长。胎儿氨基酸代谢的相关方面在正常妊娠和胎儿宫内发育迟缓的影响，将进行讨论。此外，还将提供来自动物实验的数据，这些实验试图确定解释人体试验中发现的不良反应的机制。最后，我们将提出新的途径，研究如何安全地使用氨基酸补充剂来治疗和/或预防IUGR。
Maternal dietary protein supplementation to improve fetal growth has been considered as an option to prevent or treat intrauterine growth restriction. However, in contrast to balanced dietary supplementation, adverse perinatal outcomes in pregnant women who received high amounts of dietary protein supplementation have been observed. The responsible mechanisms for these adverse outcomes are unknown. This review will discuss relevant human and animal data to provide the background necessary for the development of explanatory hypotheses and ultimately for the development therapeutic interventions during pregnancy to improve fetal growth. Relevant aspects of fetal amino acid metabolism during normal pregnancy and those pregnancies affected by IUGR will be discussed. In addition, data from animal experiments which have attempted to determine mechanisms to explain the adverse responses identified in the human trials will be presented. Finally, we will suggest new avenues for investigation into how amino acid supplementation might be used safely to treat and/or prevent IUGR.