SHEAR-STRESS AND AORTIC HISTAMINE SYNTHESIS
SHEAR-STRESS AND AORTIC HISTAMINE SYNTHESIS
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DOI：
10.1152/ajpheart.1978.234.6.h701
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发表时间：
1978-01-01
影响因子：
--
通讯作者：
HOLLIS, TM
中科院分区：
文献类型：
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作者：
DEFORREST, JM;HOLLIS, TM
主动脉组胺形成能力（HFC）的关系进行了检查所施加的平均剪切应力强度的脉动灌注兔动脉与无血小板血液1小时的时间。平均剪切应力强度范围为22-109 dyn/cm 2。剪切应力和HFC之间存在高度相关性，其由回归方程y = 0.28x - 6.1描述，其中y = HFC，x =平均剪切应力强度。组胺形成的速率对所施加的剪切应力敏感，主动脉的组氨酸脱羧酶系统可能具有作为所施加的血流动力学应力和由此产生的主动脉壁对大分子的抵抗力改变之间的偶联剂的潜力。[This应力（即，血液动力学介导的内皮细胞损伤）引起动脉透壁通透性的增加，这被认为是动脉粥样硬化发病机制中的初始事件。
Aortic histamine-forming capacity (HFC) was examined in relationship to the applied mean shear stress intensity created by pulsatile perfusion of rabbit aortas with platelet-free blood for a 1 h period. Mean shear stress intensities ranged from 22-109 dyn/cm2. A high correlation exists between the shear stress and the HFC which is described by the regression equation y = 0.28x - 6.1, where y = HFC and x = mean shear stress intensity. The rate of histamine formation is sensitive to the applied shear stress, and the histidine decarboxylase system of the aorta may have the potential of serving as a coupling agent between applied hemodynamic stress and resultant alterations in aortic wall resistance to macromolecules. [This stress (i.e., hemodynamic-mediated endothelial cell injury) causes an increase in arterial transmural permeability which is considered an initial event in atherosclerotic pathogenesis.].