Angiogenesis in oral cancer.
Angiogenesis in oral cancer.
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DOI：
10.1002/j.0022-0337.2001.65.11.tb03489.x
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发表时间：
2001-11
影响因子：
2.3
通讯作者：
R. Hasina;M. Lingen
中科院分区：
文献类型：
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作者：
R. Hasina;M. Lingen
头颈部鳞状细胞癌（HNSCC）是一种侵袭性恶性肿瘤，在长期暴露于酒精和烟草产品后发展。暴露于这些试剂导致在调节各种细胞功能中重要的基因的改变。这种调节的丧失允许肿瘤细胞通过允许细胞执行有助于肿瘤生长的功能而以不受抑制的方式存活和生长。其中一些重要的变化包括获得永生和侵入组织和/或转移到其他部位的能力，以及获得诱导血管生成的能力。血管生成，即新血管从先前存在的血管生长，是一种复杂的现象，是实体肿瘤持续生长和存活所绝对需要的。如果没有新的血管提供营养和清除废物，肿瘤将无法生长直径超过2-3毫米。因此，可以预见其在治疗和预防恶性肿瘤如HNSCC中的潜在作用。化学预防的概念在HNSCC中是极其重要的，因为患者通常在上呼吸消化道粘膜中发展多个独立的病变。因此，这种疾病的综合治疗不仅要解决最初的原发性肿瘤，而且要防止潜伏在其余粘膜表面的癌前病变的进展。这篇综述将概述肿瘤细胞中发生的导致血管生成表型转变的基本变化。此外，还将讨论抗血管生成药物在癌症治疗中的应用现状。最后，本文将提出一个理由，使用多种抗血管生成药物作为一种手段，开发新的化疗和化学预防方案，可能会导致减少患者的毒性，同时保持类似的临床疗效。
Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy that develops after years of chronic exposure to alcohol and tobacco products. Exposure to these agents results in alterations of genes that are important in the regulation of various cellular functions. This loss of regulation allows the tumor cells to survive and grow in an unchecked manner by allowing the cells to perform functions that contribute to the growth of the tumor. Some of these important changes include the acquisition of immortality and the ability to invade tissue and/or metastasize to other sights, as well as acquiring the ability to induce angiogenesis. Angiogenesis, the growth of new blood vessels from pre-existing ones, is a complex phenomenon that is absolutely required for the continued growth and survival of solid neoplasms. Without new blood vessels to provide nutrients and remove waste, tumors would be unable to grow larger than 2-3 mm in diameter. Therefore, one could envision its potential role in both the treatment and prevention of malignancies such as HNSCC. The concept of chemoprevention is extremely important in HNSCC since patients often develop multiple independent lesions throughout the mucosa of the upper aerodigestive tract. Therefore, the comprehensive treatment of this disease must address not only the initial primary neoplasm, but also prevent the progression of the premalignant lesions lurking throughout the rest of the mucosal surfaces. This review will outline the basic changes that occur in tumor cells that result in the switch to angiogenic phenotype. In addition, it will discuss the present status of using antiangiogenic agents in the treatment of cancer. Finally, this paper will present a rationale for the use of multiple antiangiogenic agents as a means of developing new chemotherapeutic and chemopreventive protocols that may result in reduced patient toxicity while maintaining similar clinical efficacies.