Recipient factors in faecal microbiota transplantation: one stool does not fit all
Recipient factors in faecal microbiota transplantation: one stool does not fit all
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DOI：
10.1038/s41575-021-00441-5
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发表时间：
2021-04-27
影响因子：
65.1
通讯作者：
Sokol, Harry
中科院分区：
文献类型：
--
作者：
Danne, Camille;Rolhion, Nathalie;Sokol, Harry
粪便微生物群移植（FMT）是治疗与肠道微生物群改变相关的慢性疾病的一种有前途的疗法。FMT治愈了90%的复发性艰难梭菌感染。然而，在复杂的疾病，如炎症性肠病，肠易激综合征和代谢综合征，其疗效仍然可变。它是公认的，捐助者的选择和样品管理是FMT成功的关键决定因素，但鲜为人知的是，受者的因素影响it.In这个角度来看，我们讨论了受体参数的影响，如遗传，免疫，微生物群和生活方式，对供体微生物群植入和临床疗效。新出现的证据支持这样一种可能性，即控制受体肠道中的炎症可能通过减少宿主免疫系统对新转移的微生物群的压力来促进植入。破解FMT植入规则和开发新的治疗策略是减轻与肠道菌群改变相关的慢性疾病负担的优先事项，如炎症性肠病。粪便菌群移植治疗一系列疾病的疗效各不相同。在这个观点中，索科尔和同事讨论了影响粪便微生物群移植成功的各种受体因素的相关性，如炎症，免疫和遗传。
Faecal microbiota transplantation (FMT) is a promising therapy for chronic diseases associated with gut microbiota alterations. FMT cures 90% of recurrent Clostridioides difficile infections. However, in complex diseases, such as inflammatory bowel disease, irritable bowel syndrome and metabolic syndrome, its efficacy remains variable. It is accepted that donor selection and sample administration are key determinants of FMT success, yet little is known about the recipient factors that affect it. In this Perspective, we discuss the effects of recipient parameters, such as genetics, immunity, microbiota and lifestyle, on donor microbiota engraftment and clinical efficacy. Emerging evidence supports the possibility that controlling inflammation in the recipient intestine might facilitate engraftment by reducing host immune system pressure on the newly transferred microbiota. Deciphering FMT engraftment rules and developing novel therapeutic strategies are priorities to alleviate the burden of chronic diseases associated with an altered gut microbiota such as inflammatory bowel disease.The efficacy of faecal microbiota transplantation for the treatment of a range of diseases varies. In this Perspective, Sokol and colleagues discuss the relevance of various recipient factors that influence faecal microbiota transplantation success such as inflammation, immunity and genetics.