Intramuscular adipose tissue determined by T1-weighted MRI at 3 T primarily reflects extramyocellular lipids
Intramuscular adipose tissue determined by T1-weighted MRI at 3 T primarily reflects extramyocellular lipids
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DOI：
10.1016/j.mri.2015.12.038
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发表时间：
2016-05-01
影响因子：
2.5
通讯作者：
Oshida, Yoshiharu
中科院分区：
文献类型：
--
作者：
Akima, Hiroshi;Hioki, Maya;Oshida, Yoshiharu
目的：本研究的目的是评估MRI测定的肌内脂肪组织（IntraMAT）含量与H-1磁共振波谱（H-1 MRS）测定的细胞内脂质（IMCL）和细胞外脂质（EMCL）或b超测定的骨骼肌回声强度之间的关系。方法：研究对象为30名男女青年和老年人。采用基于直方图形状的阈值技术，从右大腿中部取t1加权MRI，测量股外侧肌（VL）和股二头肌（BF）的IntraMAT含量。采用H-1 mrs超声从右大腿中部的VL和BF处测量IMCL和EMCL，基于灰度级测量回波强度进行定量分析。结果：MRI IntraMAT含量与VL、BF的EMCL （VL, r = 0.506, P < 0.01； BF, r = 0.591, P < 0.001）、回波强度与VL、BF的EMCL （VL, r = 0.485, P < 0.05； BF, r = 0.648, P < 0.01）有显著相关性。IntraMAT含量与VL、BF的回波强度也呈显著相关（VL, r = 0.404, P < 0.05； BF, r = 0.493, P < 0.01）。结论：我们的研究表明，t1加权MRI在3t时测定的IntraMAT含量主要反映了人类骨骼肌的细胞外脂质，而不是细胞内脂质。(C) 2015爱思唯尔公司版权所有。
Purpose: The purpose of this study was to assess relationships between intramuscular adipose tissue (IntraMAT) content determined by MRI and intramyocellular lipids (IMCL) and extramyocellular lipids (EMCL) determined by H-1 magnetic resonance spectroscopy (H-1 MRS) or echo intensity determined by B-mode ultrasonography of human skeletal muscles.Methods: Thirty young and elderly men and women were included. T1-weighted MRI was taken from the right mid-thigh to measure IntraMAT content of the vastus lateralis (VL) and biceps femoris (BF) using a histogram shape-based thresholding technique. IMCL and EMCL were measured from the VL and BF at the right mid-thigh using H-1 MRS. Ultrasonographic images were taken from the VL and BF of the right mid-thigh to measure echo intensity based on gray-scale level for quantitative analysis.Results: There was a significant correlation between IntraMAT content by MRI and EMCL of the VL and BF (VL, r = 0.506, P < 0.01; BF, r = 0.591, P < 0.001) and between echo intensity and EMCL of the VL and BF (VL, r = 0.485, P < 0.05; BF, r = 0.648, P < 0.01). IntraMAT content was also significantly correlated with echo intensity of the VL and BF (VL, r = 0.404, P < 0.05; BF, r = 0.493, P < 0.01).Conclusion: Our study suggests that IntraMAT content determined by T1-weighted MRI at 3 T primarily reflects extramyocellular lipids, not intramyocellular lipids, in human skeletal muscles. (C) 2015 Elsevier Inc. All rights reserved.