Discrimination between Alzheimer disease, mild cognitive impairment, and normal aging by using automated segmentation of the hippocampus
Discrimination between Alzheimer disease, mild cognitive impairment, and normal aging by using automated segmentation of the hippocampus
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DOI：
10.1148/radiol.2481070876
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发表时间：
2008-07-01
期刊：
影响因子：
19.7
通讯作者：
Lehericy, Stephane
中科院分区：
文献类型：
--
作者：
Colliot, Olivier;Chetelat, Gael;Lehericy, Stephane
目的：以AD和MCI患者的既定标准作为参考标准，前瞻性评估自动海马体积测量法在区分阿尔茨海默病（AD）患者、轻度认知障碍（MCI）患者和老年对照中的准确性。材料和方法：区域伦理委员会批准了本研究，并获得了所有参与者的书面知情同意书。研究纳入25例AD患者（男性11例，女性14例，平均年龄+/-标准差[SD] 73岁+/- 6岁，最小精神状态检查（MMSE）评分24.4 +/- 2.7），24例遗忘性MCI患者（男性10例，女性14例，平均年龄+/- SD 74岁+/- 8岁，MMSE评分27.2 +/- 1.4）和25例老年健康对照（男性13例，女性12例，平均年龄+/- SD 64岁+/- 8岁）。对于每个参与者，海马体在高空间分辨率的三维t1加权磁共振（MR）图像上被自动分割。分割是通过使用最近开发的软件进行的，该软件允许以最小的用户输入进行快速分割。各组海马体积差异采用Student t检验。为了获得P值、正确的分类率、灵敏度和特异性的稳健估计，使用了自举方法。结果：在所有患者组中均检测到显著的海马体积减少(AD患者与对照组相比减少32%，P
Purpose: To prospectively evaluate the accuracy of automated hippocampal volumetry to help distinguish between patients with Alzheimer disease ( AD), patients with mild cognitive impairment (MCI), and elderly controls, by using established criteria for patients with AD and MCI as the reference standard.Materials and Methods: The regional ethics committee approved the study and written informed consent was obtained from all participants. The study included 25 patients with AD (11 men, 14 women; mean age +/- standard deviation [SD], 73 years +/- 6; Mini-Mental State Examination (MMSE) score, 24.4 +/- 2.7), 24 patients with amnestic MCI (10 men, 14 women; mean age +/- SD, 74 years +/- 8; MMSE score, 27.2 +/- 1.4) and 25 elderly healthy controls (13 men, 12 women; mean age +/- SD, 64 years +/- 8). For each participant, the hippocampi were automatically segmented on three-dimensional T1-weighted magnetic resonance (MR) images with high spatial resolution. Segmentation was performed by using recently developed software that allows fast segmentation with minimal user input. Group differences in hippocampal volume were assessed by using Student t tests. To obtain robust estimates of P values, the correct classification rate, sensitivity, and specificity, bootstrap methods were used.Results: Significant hippocampal volume reductions were detected in all groups of patients (-32% in AD patients vs controls, P