Relationships of serum ferritin, transferrin saturation, and HFE mutations and self-reported diabetes in the hemochromatosis and iron overload screening (HEIRS) study
Relationships of serum ferritin, transferrin saturation, and HFE mutations and self-reported diabetes in the hemochromatosis and iron overload screening (HEIRS) study
复制标题
DOI：
10.2337/dc05-1592
复制
发表时间：
2006-09-01
期刊：
影响因子：
16.2
通讯作者：
Sholinsky, Phyliss
中科院分区：
文献类型：
--
作者：
Acton, Ronald T.;Reboussin, David M.;Sholinsky, Phyliss
目的-我们评估了自报糖尿病与血清铁蛋白浓度，转铁蛋白饱和度（TfSat），和HFE C282 Y和H63 D突变在血色病和铁超负荷筛选（HEIRS）study.RESEARCH设计和方法-在97,470名参与者进行了分析，在五个领域中心招募的六个种族/民族群体。参与者谁报告以前的诊断糖尿病和/或血色素沉着症或铁超载与参与者谁没有报告以前的diagnosis.RESULTS -糖尿病的总体患病率为13.8%，患病率最高的是在太平洋岛民（20.1%）。在所有糖尿病患者中，2.0%的人报告他们也有血色沉着病或铁超载。在所有种族/民族的糖尿病女性患者和患有糖尿病的美国土著男性患者中，平均血清铁蛋白浓度显著高于非糖尿病患者。亚洲男性糖尿病患者的平均血清铁蛋白浓度显著低于非糖尿病患者。除美国土著妇女外，所有种族/民族的糖尿病患者的平均TfSat均低于非糖尿病患者。糖尿病与HFE基因型无显著关联。除C282 Y/C282 Y和C282 Y/H63 D基因型外，糖尿病妇女的平均血清铁蛋白浓度高于非糖尿病妇女（P < 0.0001）。对数血清铁蛋白浓度与糖尿病在logistic回归分析中显着相关，调整后的年龄，性别，种族/民族，HFE基因型，和field center.CONCLUSIONS -血清铁蛋白浓度与糖尿病相关，即使在低于那些通常与血色素沉着症或铁超载。
OBJECTIVE - We evaluated the associations of self-reported diabetes with serum ferritin concentration, transferrin saturation (TfSat), and HFE C282Y and H63D mutations in six racial/ethnic groups recruited at five field centers in the Hemochromatosis and Iron Overload Screening (HEIRS) study.RESEARCH DESIGN AND METHODS - Analyses were conducted on 97,470 participants. Participants who reported a previous diagnosis of diabetes and/or hemochromatosis or iron overload were compared with participants who did not report a previous diagnosis.RESULTS - The overall prevalence of diabetes was 13.8%; the highest prevalence was in Pacific Islanders (20.1%). Of all participants with diabetes, 2.0% reported that they also had hemochromatosis or iron overload. The mean serum ferritin concentration was significantly greater in women with diabetes in all racial/ethnic groups and in Native-American men with diabetes than in those without diabetes. The mean serum ferritin concentration was significantly lower in Asian men with diabetes than in those without diabetes. Mean TfSat was lower in participants with diabetes from all racial/ethnic groups except Native-American women than in those without diabetes. There was no significant association of diabetes with HFE genotype. The mean serum ferritin concentration was greater (P < 0.0001) in women with diabetes than in those without diabetes for HFE genotypes except C282Y/C282Y and C282Y/H63D. Log serum ferritin concentration was significantly associated with diabetes in a logistic regression analysis after adjusting for age, sex, racial/ethnic group, HFE genotype, and field center.CONCLUSIONS - Serum ferritin concentration is associated with diabetes, even at levels below those typically associated with hemochromatosis or iron overload.